We are interested in understanding biological phenomena related to biomembranes at the molecular level. We focus on protein folding at membrane surfaces and signal transduction across biomembranes through G protein-coupled receptors (GPCRs). Using techniques in molecular biology and chemical biology, we express and purify recombinant soluble and membrane proteins. We then apply second-order laser spectroscopy and biophysical methods to obtain thermodynamic and kinetic information to investigate structure and functions of the proteins.