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The ability to prevent and effectively treat benign and malignant diseases of the prostate requires defining specific factors that initiate, promote, and maintain prostatic growth. Our laborartory has been focusing on the regulation of prostatic growth and characterizing it in the human fetus. The development of the human fetal prostate is an androgen-dependent event possibly mediated by growth factor that are elaborated by the prostatic mesenchyme. Our current projects include investigation the biology of prostatic growth regulation at the molecular, cellular, and organ level to demonstrate that: 1) the proliferative activity of the human prostate is intense during fetal development; 2) the fetal prostate is primarily mesenchyme and the mesenchyme induces glandular formation; 3) fetal proliferation of the human prostate is characterized by temporal and cellular compartmental expression of growth factors and their receptors; and 4) steriod hormone receptors are expressed by the mesenchyme during fetal development of the prostate.
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The Journal of Urologyno. Supplement 4 (2023): E464-E465
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Scientific reportsno. 1 (2023): 18227
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Journal of Urologyno. Supplement 5 (2022)
Journal of Urologyno. Supplement 3 (2021)
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