Dr. Engle received her B.A. from Middlebury College and her M.D. from Johns Hopkins University School of Medicine. She trained in pediatrics at Johns Hopkins, in neuropathology at Massachusetts General Hospital, and in adult and child neurology in the Longwood Neurology Training Program and Boston Children’s Hospital. Nearing the end of her neurology residency, Dr. Engle cared for a toddler born with a complex eye movement disorder that segregated in his family as a dominant trait. Interested in the etiology of his rare disorder, she pursued a research fellowship in genetics. Dr. Engle’s research career now spans from patients through genetics to molecular mechanisms in order to understand human brainstem and cranial nerve development. Her work has defined the human congenital cranial dysinnervation disorders and has been recognized by high-profile publications, her appointment as a Howard Hughes Medical Institute Investigator, and by receipt of multiple honors. Dr. Engle continues to care for patients, primarily consulting for children and adults with rare eye movement and other cranial nerve disorders. She teaches in both the clinical and laboratory settings, and has served on multiple committees that set the direction for neuroscience and ophthalmology research both locally and nationally.