Her research interest centres around musculoskeletal aging. Based at the MRC Lifecourse Epidemiology Centre, she is particularly interested in how events early in life interact with adult lifestyle factors to determine how we age. Professor Dennison is author of over 420 journal articles.
In recent years she has served as Chair of the National Osteoporosis Society Grants Committee, and as a member of the National Osteoporosis Society Clinical and Scientific Committee. She sits on the International Osteoporosis Foundation Committee of the Scientific Advisers, and chaired the British Society of Rheumatology Biologics Register Steering Committee. She has also been a clinical member of the Bone Research Society Committee. Currently she sits on the Versus Arthritis Research Committee and the BSR Hebedren Committee. Professor Dennison also sits on many editorial boards, including Osteoporosis International, Calcified Tissue International, Aging Clinical Experimental Research and the Journal of Developmental Health and Adult Disease. She is Associate Editor for Frontiers Epidemiology of Women's Health.