E. Errasti-Murugarren

In the last years as Research Associate in the laboratory of Manuel Palacín I have led the structural biology section, resulting in the publication of the structures of a bacterial homolog of the LATs and of the human amino acid transporter LAT2/CD98hc, as first and corresponding author, respectively. Since November 2021 I have my own position as Lecturer Professor at the University of Barcelona, which allows me to develop a new line of research independently, based on my previous experience, but different from that developed in Manuel Palacín's group. This represents my first project as an independent PI of this new line of research. High quality scientific production 30 publications, including 22 original articles, 7 reviews and 1 book chapter. 15 publications as first author and 5 as corresponding author. 25 publications in Q1; h index: 15; 674 total cites; 71,6 cites/year (5 years) MDPI reviewer. 5 articles reviewed in 2021. Member of the Membranes journal Editorial Board Training and leadership capacity 12 student in 10 years. 5 Master students, 3 undergraduate thesis students and 4 PhD students. 5 articles as corresponding author. 2 projects as principal investigator. Expertise in membrane protein structural and functional biology Elucidation of the molecular basis of substrate recognition and conformational changes of a bacterial distant homologue (AdiC) of the human LAT transporters (Kowalczyk et al., PNAS. 2011). Identification of the molecular determinants of apparent affinity asymmetry in substrate interaction of a bacterial LAT transporter (Errasti-Murugarren et al., Nat. Comm. 2019). First membrane transporter solved from scratch in Spain. Structural and functional characterization of human LAT2/CD98hc (SLC7A8/SLC3A2) heterodimer (Rodriguez et al., PNAS. 2021). Association of LAT2 mutations to age-related hearing loss (Espino-Guarch et al., eLife. 2018) and cataracts (Knöpfel et al., Front. Physiol. 2019). Elucidation of SLC28 family members pathophysiological roles. Identification of human CNT3 (SLC28A3) as a key player in transepithelial flux of nucleosides and derived drugs (Errasti-Murugarren et al., J. Physiol. 2007). Functional characterization of a novel human ENT3 (SLC29A3) mutation associated to H-syndrome (Huber-Ruano et al., BBRC. 2013). Ongoing collaborations Prof. Raul Estevez (University of Barcelona): Structural and functional characterization of MLC1-GlialCAM complex. Dr. Oscar Llorca (CNIO Madrid): hLAT2/CD98hc, hAsc1/CD98hc and MLC1-GlialCAM structural resolution. Dr. Núria Casals (UIC): Purification of carnitine-palmitoyl transferases 1A and C (CPT1A and C). Dr. Josep Dalmau (IDIBAPS, Hospital Clínic): Purification of GluN1 NMDAR receptor.