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My lab is interested in Molecular Structure and Self-Assembly at the Nano-Scale.
The central dogma in the study of protein folding suggests that the thermodynamically-favorable state of proteins under physiological conditions is their folded one. However, there are number of cases in which the favorable states of proteins are rather unfolded, partially folded (e.g., “molten globular”), or misfolded (e.g., nonspecific aggregates or amyloid fibrils). These observations lead to much interest in the significance and mechanism of formation of such unfolded, misfolded or partially folded structures in physiological as well as pathological conditions.
In our lab we utilize a variety of biochemical, biophysical and molecular biology methodologies to study the mechanism and significance of protein unfolding and misfolding. The experimental systems used are diverse and the partial list includes several bacterial toxin-antidote systems, type II diabetes-related amyloidogenic proteins and peptides, and the VHL tumor suppressor protein. We also study the mechanism of non-specific aggregation of generic unrelated proteins. Another line of research is directed toward the elucidation of the mechanism of action of chemical chaperons and their effect on folding, aggregation and amyloid formation.
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JOURNAL OF MATERIALS CHEMISTRY Bno. 11 (2024): 2855-2868
Hui Yuan,Pierre-Andre Cazade, Shuaikang Zhou,Linda J. W. Shimon,Chengqian Yuan,Dan Tan, Cunshun Liu,Wei Fan,Vijayakanth Thangavel,Yi Cao,Damien Thompson,Xuehai Yan,
SMALLno. 17 (2024)
Thangavel Vijayakanth, Sneha Dasgupta, Pragati Ganatra,Sigal Rencus-Lazar,Aamod V. Desai,Shyamapada Nandi, Rahul Jain,Santu Bera,Andy I. Nguyen,Ehud Gazit,Rajkumar Misra
CHEMICAL SOCIETY REVIEWSno. 8 (2024): 3640-3655
Shuang Chen,Yufan Xia, Ran Zeng,Zhen Luo,Xingxing Wu,Xuzhi Hu,Jian Lu,Ehud Gazit,Hongge Pan,Zijian Hong,Mi Yan,Kai Tao,
Science Advancesno. 10 (2024): eadn2265-eadn2265
Lujing Gao, Zixuan Liu, Daniel Dikovsky,Jiqian Wang,Deqing Mei,Lihi Adler-Abramovich,Ehud Gazit,Kai Tao
Shira Shaham-Niv,Assaf Ezra,Dor Zaguri, Stav Roni Shotan,Elvira Haimov,Hamutal Engel, Tamara Brider,Luba Simhaev, Haim Michael Barr,Lihi Adler-Abramovich,Ehud Gazit
Biophysical chemistry (2024): 107215-107215
Vijay Kumar,Vibha Kaushik, Sourav Kumar,Shon A. Levkovich, Priya Gupta,Dana Laor Bar-Yosef,Ehud Gazit,Daniel Segal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2024): 149250-149250
ACS NANOno. 3 (2024): 2421-2433
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