Our research encompasses all aspects of synthetic organic chemistry, with a particular focus on the total synthesis of biologically active molecules, and the development of new reactions including cascade processes. We aim to use the exciting and challenging chemical structures displayed by bioactive natural products to inspire the development of new reactions. High importance is placed on both reaction generality (to demonstrate wide substrate scope), and on finding additional uses of the reaction products (to increase method utility). Within the theme of reaction development, we have particular interests in the use of metal-mediated reactions to rapidly construct complex functional molecules, and in new applications of organosilicon chemistry.