He has a range of research interests including endoscopic sinus surgery, laryngology, otology, audiology and vestibology. His main interest over the years has been in rhinology, with a particular focus on type 2 inflammation in respiratory disease and in particular allergic rhinitis, non-allergic rhinitis, rhinosinusitis, and chronic rhinosinusitis with nasal polyps (CRSwNP).

Prof. De Corso has contributed to more than 140 peer-reviewed publications and has conducted several clinical studies of patients undergoing innovative therapies, such as biologics for severe uncontrolled CRSwNP and refractory eosinophilic otitis media associated with CRSwNP. He participated as principal investigator of several randomized controlled trials on the use of biologic drugs in rhinology, particularly in chronic rhinosinusitis with nasal polyps, and has been the scientific director of several courses in rhinology, particularly on the use of biologics in the treatment of CRSwNP, since 2018.

Prof. De Corso has held the position of Associate Editor of Acta Otorhinolaryngologica Italica, the official journal of the Italian Society of Otorhinolaryngology, since 2016. He is a member of the Editorial Board of the International Journal of Rhinology and a reviewer for many international journals. He is a member of the Directive Board of the Italian Academy of Rhinology, the European Forum for Research and Education in Allergy and Airway Diseases, the EPOS Steering Group, and the Commission of the Italian Society of Otolaryngology for the use of biological drugs in rhinology, as well as co-author of several position papers, guidelines, and expert opinions on the treatment of chronic rhinosinusitis with nasal polyps.