基本信息
views: 40
Career Trajectory
Bio
主要从事于基于人工智能技术的高效化学信息学和计算机辅助药物分子设计方法和应用研究,针对药物研发中的三个关键技术瓶颈问题(生物活性分子的发现、成药性和安全性预测及选择性/脱靶效应/耐药性评估),聚焦基于结构/配体的虚拟筛选方法、成药性理论预测、分子靶标识别和分子智能生成和优化展开了系统和深入的多学科交叉方法学研究,实现药物分子“设计-合成-测试-分析”的自动闭环设计系统,并把发展的方法与实验平台无缝衔接用于多个重要靶点的药物分子设计和生物活性分子的作用靶标识别,开发出多类具有全新结构的抗肿瘤先导化合物并揭示了多种生物活性分子的耐药新机制。
Research Interests
Papers共 272 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Journal of medicinal chemistry (2025)
NATURE MACHINE INTELLIGENCEno. 11 (2024)
Expert systems with applications (2024): 122498-122498
JOURNAL OF CHEMICAL INFORMATION AND MODELINGno. 8 (2024): 3080-3092
Nature protocolsno. 4 (2024): 1105-1121
Wen-Jing Ai,Jing Li,Dongsheng Cao,Shao Liu,Yi-Yun Yuan, Yan Li,Gui-Shan Tan,Kang-Ping Xu,Xia Yu,Fenghua Kang,Zhen-Xing Zou,Wen-Xuan Wang
JOURNAL OF NATURAL PRODUCTSno. 4 (2024): 743-752
JOURNAL OF MEDICINAL CHEMISTRYno. 11 (2024): 9575-9586
NUCLEIC ACIDS RESEARCHno. W1 (2024): W439-W449
Wentao Wang, Qiaoying Yan,Qingquan Liao, Xinyuan Jin,Yinyin Gong,Linlin Zhuo, Xiangzheng Fu,Dongsheng Cao
Journal of Pharmaceutical Analysis (2024)
Chao Shen,Jianfei Song,Chang-Yu Hsieh,Dongsheng Cao,Yu Kang,Wenling Ye,Zhenxing Wu,Jike Wang,Odin Zhang,Xujun Zhang, Hao Zeng,Heng Cai, Yu Chen, Linkang Chen, Hao Luo, Xinda Zhao, Tianye Jian, Tong Chen,Dejun Jiang,Mingyang Wang,Qing Ye,Jialu Wu,Hongyan Du, Hui Shi,Yafeng Deng,Tingjun Hou
JOURNAL OF CHEMICAL INFORMATION AND MODELINGno. 14 (2024): 5381-5391
Load More
Author Statistics
#Papers: 271
#Citation: 11195
H-Index: 48
G-Index: 101
Sociability: 7
Diversity: 3
Activity: 201
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn