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职业迁徙
个人简介
Description of Research Expertise
Research Interests
Mechansims and determinants of HIV induced neuronal injury. Neuronal cell responses to virus induced injury.
Key words: neuron, hippocampus, apoptosis, gene expression, single-cell mRNA, HIV, chemokine receptor, NMDA receptor.
Description of Research
The Kolson lab focuses the roles for inflammation, immune activation, and oxidative stress in virus-induced neurodegeneration. Major areas of focus involve immunodeficiency viruses (HIV and simian immunodeficiency virus/SIV). Research in the lab involves analysis of human brain specimens from HIV infected individuals, studies of neurodegeneration and neuroinflammation in SIV-infected Rhesus macaques, in vitro modeling of HIV-induced neurodegeneration, and oxidative stress responses in vitro and in vivo. We also study responses to HIV infection in cohorts of individuals participating in national/international clinical cohort trials.
We have developed a unique in vitro model of HIV-induced neurodegeneration, and we combine this model with analyses of autopsied human brains from HIV infected individuals and SIV-infected Rhesus macaques to identify pathways of neurodegeneration and modulating effects of host antioxidant response genes. We have identified a defect in the human host anti-oxidant response to HIV infection of the brain that determines an individual's risk for neurodegeneration and neurocognitive impairment in HIV infection. This has led to a pilot proof-of-principle neuroprotection drug study in Rhesus macaques. In neurogenetic studies, we have linked a common genetic polymorphism ((GT)n dinucleotide repeat length variation) in the antioxidant gene heme oxygenase-1, to risk for neuroinflammation and neurocognitive impairment in HIV-infected persons.
Dr. Kolson has had active NIH funding for his laboratory since 1992, and he has trained PhD and MD-PhD students in his lab. Several of his students have been awarded a Ruth L. Kirschtein (F30, F31) National Research Service Award (NRSA) to support their own research training. He is active in training graduate and medical students as a laboratory research mentor, and he also gives interested trainees an opportunity for exposure to translational aspects of neurovirology/neuroimmunology research by offering students an opportunity to attend his weekly multiple sclerosis outpatient clinic.
Description of Clinical Expertise
multiple sclerosis, neurological complication of AIDS
Research Interests
Mechansims and determinants of HIV induced neuronal injury. Neuronal cell responses to virus induced injury.
Key words: neuron, hippocampus, apoptosis, gene expression, single-cell mRNA, HIV, chemokine receptor, NMDA receptor.
Description of Research
The Kolson lab focuses the roles for inflammation, immune activation, and oxidative stress in virus-induced neurodegeneration. Major areas of focus involve immunodeficiency viruses (HIV and simian immunodeficiency virus/SIV). Research in the lab involves analysis of human brain specimens from HIV infected individuals, studies of neurodegeneration and neuroinflammation in SIV-infected Rhesus macaques, in vitro modeling of HIV-induced neurodegeneration, and oxidative stress responses in vitro and in vivo. We also study responses to HIV infection in cohorts of individuals participating in national/international clinical cohort trials.
We have developed a unique in vitro model of HIV-induced neurodegeneration, and we combine this model with analyses of autopsied human brains from HIV infected individuals and SIV-infected Rhesus macaques to identify pathways of neurodegeneration and modulating effects of host antioxidant response genes. We have identified a defect in the human host anti-oxidant response to HIV infection of the brain that determines an individual's risk for neurodegeneration and neurocognitive impairment in HIV infection. This has led to a pilot proof-of-principle neuroprotection drug study in Rhesus macaques. In neurogenetic studies, we have linked a common genetic polymorphism ((GT)n dinucleotide repeat length variation) in the antioxidant gene heme oxygenase-1, to risk for neuroinflammation and neurocognitive impairment in HIV-infected persons.
Dr. Kolson has had active NIH funding for his laboratory since 1992, and he has trained PhD and MD-PhD students in his lab. Several of his students have been awarded a Ruth L. Kirschtein (F30, F31) National Research Service Award (NRSA) to support their own research training. He is active in training graduate and medical students as a laboratory research mentor, and he also gives interested trainees an opportunity for exposure to translational aspects of neurovirology/neuroimmunology research by offering students an opportunity to attend his weekly multiple sclerosis outpatient clinic.
Description of Clinical Expertise
multiple sclerosis, neurological complication of AIDS
研究兴趣
论文共 57 篇作者统计合作学者相似作者
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ANNALS OF NEUROLOGY (2023): S53-S54
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Biomedicinesno. 5 (2023): 1387-1387
Neurology(R) neuroimmunology & neuroinflammationno. 1 (2023)
Biomedicinesno. 2 (2023): 377
medRxiv (Cold Spring Harbor Laboratory) (2022)
JOURNAL OF LEUKOCYTE BIOLOGYno. 5 (2022): 951-953
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作者统计
#Papers: 34
#Citation: 1094
H-Index: 16
G-Index: 33
Sociability: 5
Diversity: 0
Activity: 0
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