All of the work being conducted in the lab is based on the application of cutting-edge genomic (next-generation DNA/RNA sequencing), epigenomic (DNA methylation, ChIPseq), and functional technologies (CRISPR/Cas9, somatic gene transfer models) to enhance our understanding of the biological underpinnings of pediatric brain tumors. A further important focus of the group is the translation of this research into practical applications for the benefit of patients. To this end, we are closely involved in the coordination of two international molecular diagnostic programs: the INFORM study for identification of possible drug targets in high-risk pediatric cancers; and the MNP2 study to investigate the value of molecular analysis as a tool for accurate classification of brain tumors.