He has an active research interest in cardiovascular disease pathophysiology and treatment. He has additional interest in commercialization of novel medical devices through start-up companies, and efficient methods of product development. He has been involved with four start-ups and successfully raised over $20 million in financing. Dr. Ku's work is supported by the National Institutes of Health, the National Science Foundation, the American Heart Association, the Mason Foundation, and the Whitaker Foundation. His collaborative work is performed with Emory University, Worcester Polytechnic Institute, Texas A&M, Nagano University, and the Swiss Federal Institute of Technology in Lausanne, Switzerland.