基本信息
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个人简介
How do some neurons survive a lifetime while others succumb to neurodegeneration? Answering this fundamental question will be critical for treating and preventing neurodegenerative diseases. Yet to answer it we first need to understand what governs neuronal survival and how cellular stresses interfere with survival mechanisms. To do this, we study the molecular pathways that promote neuronal survival with a particular focus on the survival of axons. We use a range of molecular, genetic, biochemical, and imaging techniques to define pathways that suppress cell death and maintain metabolic support. We then ask how stresses—including misfolded proteins, physical injury, and inflammation—disrupt these survival pathways to promote neurodegeneration. Our ultimate goal is to define how a neuron reacts to its environment and how environmental stimuli affect the balance between survival and death. This approach will allow us to understand how neurodegeneration occurs and to identify novel therapeutic targets.
研究兴趣
论文共 115 篇作者统计合作学者相似作者
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Yuri L. Sosero,Sara Bandres-Ciga,Bart Ferwerda, Maria T. P. Tocino, Diaz R. Belloso,Pilar Gomez-Garre,Johann Faouzi,Pille Taba,Lukas Pavelka,Taina M. Marques,Clarissa P. C. Gomes,Alexey Kolodkin,Patrick May,Lukasz M. Milanowski,Zbigniew K. Wszolek,Ryan J. Uitti,Peter Heutink,Jacobus J. van Hilten,David K. Simon,Shirley Eberly,Ignacio Alvarez,Lynne Krohn,Eric Yu,Kathryn Freeman,Uladzislau Rudakou,Jennifer A. Ruskey,Farnaz Asayesh,Manuel Menendez-Gonzalez,Pau Pastor,Owen A. Ross,Rejko Krueger,Jean-Christophe Corvol,Sulev Koks,Pablo Mir,Rob M. A. De Bie,Hirotaka Iwaki,Ziv Gan-Or
MOVEMENT DISORDERS (2024)
medRxiv (Cold Spring Harbor Laboratory) (2024)
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesityno. 1 (2024): 1-8
Tingtin Liu,Huanhuan Wang, Daniel Y. Kutsovsky, Michael Iskols, Hongjie Chen,Christine Y. J. Ohn,Nandan Patel,Jing Yang,David J. Simon
Brain Sciencesno. 7 (2023)
David K. Simon, Nuno Mendonca,Joerg Holenz, Jennifer Liu,Guillermo Castilla-Fernandez,Miguel M. Fonseca
MOVEMENT DISORDERS (2023): S10-S11
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Xv-Shen Ding, Li Gao,Zheng Han,Simona Eleuteri,Wei Shi, Yun Shen, Zi-Yao Song,Mingming Su, Qian Yang,Yan Qu,David K Simon,Xue-Lian Wang,Bao Wang
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#Papers: 115
#Citation: 8184
H-Index: 37
G-Index: 84
Sociability: 7
Diversity: 3
Activity: 179
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