Research Interests signal transduction, immunology, cancer, leukemia, kinase, apoptosis Research Abstract Lymphocytes circulate through the blood and lymphoid tissues in a resting state. Upon encountering antigens, they become activated to proliferate and differentiate. Lymphocytes also respond to other environmental cues, including cytokines and cell surface proteins on neighboring cells. The transmission of signals from outside the cell to the inside to modulate cell behavior is termed signal transduction.