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We are studying the biochemistry, structure and function of these E3 ligases, as well as their physiological functions using cells and model organisms. Moreover, we have developed proteomic methodologies to globally identify substrates for E3 ubiquitin ligases and have subsequently focused our studies on some of the membrane proteins that were identified in these screens (eg the sodium channel ENaC, the FGF receptor, and several others). These studies are relevant to human diseases such as hypertension, cystic fibrosis (CF) and cancer.Other related project in the lab focus on two other membrane proteins: CFTR, the protein that is mutated in CF, for which we are developing assays and small molecules that can rescue the major mutation in this disease, and PTPsigma, a tyrosine phosphatase that malfunctions in Inflammatory Bowel Disease.
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论文共 167 篇作者统计合作学者相似作者
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Yu-Xi Xiao, Seon Yong Lee, Magali Aguilera Uribe,Reuben Samson,Aaron Au, Khanna Yukti,Zetao Liu,Ran Cheng, Kamaldeep Aulakh,Jiarun Wei,Adrian Granda Farias, Taylor Reilly,
biorxiv(2024)
Physiology (Bethesda, Md.) (2023)
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Scientific Reportsno. 1 (2023): 1-9
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Daniela Rotin,Avinash Persaud, Larry T. Patterson, Joshua Zaritsky, Thomas R. Kleyman, Mathieu J. Lemaire
Journal of the American Society of Nephrologyno. 11S (2023): 83-83
Bekir Altas, Hong-Jun Rhee,Anes Ju,Hugo Cruces Solis,Samir Karaca,Jan Winchenbach, Oykum Kaplan-Arabaci,Manuela Schwark,Mateusz C. Ambrozkiewicz, Chungku Lee,Lena Spieth,Georg L. Wieser,
JOURNAL OF CELL BIOLOGYno. 1 (2023)
Comprehensive Physiologypp.2017-2045, (2021)
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