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Dr. Goldberg does basic research on the biology of malaria and identification of drug targets. Parasites have evolved many clever ways to infect their hosts and develop within them. Researching these processes at a molecular level should lead to treatment or prevention of parasitic infections that afflict most of humanity. His laboratory currently has 4 graduate students, 2 postdocs, one pediatric ID fellow, one technician and a research associate professor. Dr. Goldberg directs the Infectious Diseases/Basic Microbial Mechanisms T32 training grant.
Intraerythrocytic malaria parasites are fascinating creatures. They have evolved many clever strategies for survival inside their host cell. Most of these adaptations are still biological mysteries. Indeed, nearly half of the Plasmodium proteome comprises proteins of unknown function. Some are species or phylum specific; others have orthologs spread widely through phylogeny. We are interested in defining the roles of such proteins, with a special focus on proteases of unknown function. We use a combination of genetic and biochemical approaches to elucidate biological roles. To help us with this analysis, we have developed a regulated protein knockdown system for the study of essential proteins. This has allowed us to define a role for Plasmodium calpain in nucleolar control of cell cycle progression and a role for the aspartic protease plasmepsin V in export of parasite proteins to the host erythrocyte.
Intraerythrocytic malaria parasites are fascinating creatures. They have evolved many clever strategies for survival inside their host cell. Most of these adaptations are still biological mysteries. Indeed, nearly half of the Plasmodium proteome comprises proteins of unknown function. Some are species or phylum specific; others have orthologs spread widely through phylogeny. We are interested in defining the roles of such proteins, with a special focus on proteases of unknown function. We use a combination of genetic and biochemical approaches to elucidate biological roles. To help us with this analysis, we have developed a regulated protein knockdown system for the study of essential proteins. This has allowed us to define a role for Plasmodium calpain in nucleolar control of cell cycle progression and a role for the aspartic protease plasmepsin V in export of parasite proteins to the host erythrocyte.
研究兴趣
论文共 238 篇作者统计合作学者相似作者
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Eva S. Istvan,Francisco Guerra,Matthew Abraham,Kuo-Sen Huang,Frances Rocamora, Haoshuang Zhao, Lan Xu,Charisse Pasaje,Krittikorn Kumpornsin,Madeline R. Luth,Haissi Cui,Tuo Yang, Sara Palomo Diaz,Maria G. Gomez-Lorenzo,Tarrick Qahash,Nimisha Mittal,Sabine Ottilie,Jacquin Niles,Marcus C. S. Lee,Manue Llinas,Nobutaka Kato,John Okombo,David A. Fidock,Paul Schimmel,Francisco Javier Gamo,Daniel E. Goldberg,Elizabeth A. Winzeler
Science translational medicineno. 686 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
ACS infectious diseasesno. 4 (2023): 1004-1021
Analytica Chimica Acta (2023): 341226
Stanley C. Xie, Yinuo Wang,Craig J. Morton,Riley D. Metcalfe,Con Dogovski,Charisse Flerida A. Pasaje,Elyse Dunn,Madeline R. Luth,Krittikorn Kumpornsin,Eva S. Istvan,Joon Sung Park,Kate J. Fairhurst,Nutpakal Ketprasit,Tomas Yeo, Okan Yildirim,Mathamsanqa N. Bhebhe,Dana M. Klug,Peter J. Rutledge,Luiz C. Godoy,Sumanta Dey,Mariana Laureano De Souza,Jair L. Siqueira-Neto,Yawei Du,Tanya Puhalovich, Mona Amini, Gerry Shami,Duangkamon Loesbanluechai,Shuai Nie,Nicholas Williamson,Gouranga P. Jana,Bikash C. Maity,Patrick Thomson, Thomas Foley,Derek S. Tan,Jacquin C. Niles,Byung Woo Han,Daniel E. Goldberg,Jeremy Burrows,David A. Fidock,Marcus C. S. Lee,Elizabeth A. Winzeler,Michael D. W. Griffin,Matthew H. Todd,Leann Tilley
Research Square (Research Square) (2023)
Suong T. Nguyen, Daniel Du, Daniel Wychrij,Matthew D. Cain, Qingping Wu,Robyn S. Klein,Ilaria Russo,Daniel E. Goldberg
Proceedings of the National Academy of Sciencesno. 26 (2023)
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#Papers: 237
#Citation: 17487
H-Index: 69
G-Index: 129
Sociability: 7
Diversity: 0
Activity: 1
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