Daniel Winer
副教授
Department of Laboratory Medicine & Pathobiology
Temerty Faculty of Medicine, University of Toronto;Buck Institute for Research on Aging;Department of Pathology, University Health Network;Division of Advanced Diagnostics - Metabolism, Toronto General Research Institute
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个人简介
The goal of our laboratory is to better understand how the immune system influences physiological processes and contributes to disease, with the aim of using this information to develop new translational diagnostics and therapeutics, including preventative vaccination strategies.
Our primary research focus is to elucidate immune mediated pathways governing obesity related insulin resistance. Obesity and its major complications, including insulin resistance, are a major global cause of morbidity and mortality, and have reached epidemic proportions. Evidence is mounting that a significant contributing cause of insulin resistance is chronic inflammation in visceral adipose tissue (VAT). This inflammation was initially thought to be driven solely by macrophages of the innate immune system attracted to dying adipocytes in fat. Recently, in collaboration with the Hospital for Sick Children and Stanford University, we have demonstrated that the adaptive immune system, including T cells, B cells and the antibodies they produce, play a significant and active role in regulating this process. This work has introduced a new " autoimmune" component to obesity related insulin resistance, and has led to new ways in thinking about metabolic disease. We continue to investigate immune mediated mechanisms in obesity and diabetes with the aim of translating our findings to help the many people afflicted by these diseases.
Our primary research focus is to elucidate immune mediated pathways governing obesity related insulin resistance. Obesity and its major complications, including insulin resistance, are a major global cause of morbidity and mortality, and have reached epidemic proportions. Evidence is mounting that a significant contributing cause of insulin resistance is chronic inflammation in visceral adipose tissue (VAT). This inflammation was initially thought to be driven solely by macrophages of the innate immune system attracted to dying adipocytes in fat. Recently, in collaboration with the Hospital for Sick Children and Stanford University, we have demonstrated that the adaptive immune system, including T cells, B cells and the antibodies they produce, play a significant and active role in regulating this process. This work has introduced a new " autoimmune" component to obesity related insulin resistance, and has led to new ways in thinking about metabolic disease. We continue to investigate immune mediated mechanisms in obesity and diabetes with the aim of translating our findings to help the many people afflicted by these diseases.
研究兴趣
论文共 103 篇作者统计合作学者相似作者
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Kenneth K Y Ting, Pei Yu, Mudia Iyayi, Riley Dow,Sharon J Hyduk, Eric Floro,Hisham Ibrahim,Saraf Karim,Chanele K Polenz,Daniel A Winer,Minna Woo,Jonathan Rocheleau,Jenny Jongstra-Bilen,Myron I Cybulsky
ImmunoHorizonsno. 1 (2024): 57-73
Fei Wu,Huixun Du,Eliah Overbey,Jangkeun Kim,Priya Makhijani, Nicolas Martin,Chad A. Lerner,Khiem Nguyen,Jordan Baechle,Taylor R. Valentino,Matias Fuentealba,Juliet M. Bartleson, Heather Halaweh,Shawn Winer,Cem Meydan,Francine Garrett-Bakelman,Nazish Sayed,Simon Melov,Masafumi Muratani,Akos A. Gerencser,Herbert G. Kasler,Afshin Beheshti,Christopher E. Mason,David Furman,Daniel A. Winer
Nature communicationsno. 1 (2024)
Christopher E Mason,James Green, Konstantinos I Adamopoulos,Evan E Afshin,Jordan J Baechle,Mathias Basner,Susan M Bailey,Luca Bielski,Josef Borg,Joseph Borg,Jared T Broddrick,Marissa Burke,Andrés Caicedo,Verónica Castañeda,Subhamoy Chatterjee,Christopher R Chin,George Church,Sylvain V Costes,Iwijn De Vlaminck,Rajeev I Desai,Raja Dhir, Juan Esteban Diaz, Sofia M Etlin, Zachary Feinstein,David Furman,J Sebastian Garcia-Medina,Francine Garrett-Bakelman,Stefania Giacomello,Anjali Gupta, Amira Hassanin,Nadia Houerbi,Iris Irby,Emilia Javorsky,Peter Jirak,Christopher W Jones,Khaled Y Kamal,Brian D Kangas,Fathi Karouia,JangKeun Kim, Joo Hyun Kim,Ashley S Kleinman,Try Lam,John M Lawler,Jessica A Lee,Charles L Limoli,Alexander Lucaci,Matthew MacKay,J Tyson McDonald,Ari M Melnick,Cem Meydan, Jakub Mieczkowski,Masafumi Muratani,Deena Najjar, Mariam A Othman,Eliah G Overbey,Vera Paar,Jiwoon Park,Amber M Paul,Adrian Perdyan,Jacqueline Proszynski,Robert J Reynolds,April E Ronca, Kate Rubins,Krista A Ryon,Lauren M Sanders, Patricia Savi Glowe, Yash Shevde,Michael A Schmidt,Ryan T Scott,Bader Shirah,Karolina Sienkiewicz,Maria A Sierra,Keith Siew,Corey A Theriot,Braden T Tierney,Kasthuri Venkateswaran,Jeremy Wain Hirschberg,Stephen B Walsh,Claire Walter,Daniel A Winer,Min Yu,Luis Zea,Jaime Mateus,Afshin Beheshti
Natureno. 8027 (2024): 995-1008
Immunityno. 9 (2024): 2010-2012
Scientific reportsno. 1 (2024): 11162-11162
Communications biologyno. 1 (2024)
Immunityno. 9 (2024): 2010-2012
Priya Makhijani,Rohini Emani,Carlos Galicia Aguirre, Wei-Chieh Mu,Anand Rane, Jenny Hong Yu Ng,Taylor R. Valentino, Max Manwaring-Mueller, Christopher Ryan Tan,Huixun Du, Fei Wu,Saad Khan,Kenneth A. Wilson,Shawn Winer,Chao Wang,Arthur Mortha,David Furman,Lisa M. Ellerby,Olga L. Rojas,Julie K. Andersen,Daniel A. Winer
bioRxiv the preprint server for biology (2024)
JangKeun Kim,Braden T. Tierney,Eliah G. Overbey,Ezequiel Dantas,Matias Fuentealba,Jiwoon Park,S. Anand Narayanan, Fei Wu,Deena Najjar,Christopher R. Chin,Cem Meydan,Conor Loy,Begum Mathyk,Remi Klotz,Veronica Ortiz,Khiem Nguyen,Krista A. Ryon,Namita Damle,Nadia Houerbi,Laura I. Patras, Nathan Schanzer,Gwyneth A. Hutchinson,Jonathan Foox,Chandrima Bhattacharya,Matthew Mackay,Evan E. Afshin,Jeremy Wain Hirschberg,Ashley S. Kleinman,Julian C. Schmidt,Caleb M. Schmidt,Michael A. Schmidt,Afshin Beheshti,Irina Matei,David Lyden,Sean Mullane, Amran Asadi,Joan S. Lenz,Omary Mzava,Min Yu,Saravanan Ganesan,Iwijn De Vlaminck,Ari M. Melnick,Darko Barisic,Daniel A. Winer,Sara R. Zwart,Brian E. Crucian,Scott M. Smith,Jaime Mateus,David Furman,Christopher E. Mason
Nature communicationsno. 1 (2024)
Brendan Cordeiro, Jeeyoon Jennifer Ahn,Saurabh Gawde, Carmen Ucciferri, Nuria Alvarez-Sanchez,Xavier S. Revelo, Natalie Stickle, Kaylea Massey,David G. Brooks,Joel M. Guthridge,Gabriel Pardo,Daniel A. Winer,Robert C. Axtell,Shannon E. Dunn
Cell metabolism (2024)
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作者统计
#Papers: 103
#Citation: 6975
H-Index: 39
G-Index: 70
Sociability: 6
Diversity: 3
Activity: 39
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