Sai Reddy is an Associate Professor of Systems and Synthetic Immunology at ETH Zurich in the Department of Biosystems Science & Engineering (D-​BSSE, Basel, Switzerland). He is the principal investigator of the Laboratory for Systems and Synthetic Immunology. Systems immunology uses quantitative measurements, computational biology and machine learning to describe and understand the complexity of the immune system. His group has developed a number of methods in systems immunology to greater understand adaptive immunity, in particular with a focus on antibody repertoire sequencing and analysis. Synthetic immunology is based on using methods in molecular and cellular engineering to control immune cell function and behavior. His group has established methods to reprogram immune cells for applications in directed evolution and cellular immunotherapy, with an emphasis on engineering the immunogenome.