Since my appointment as Consultant Immunologist to St. James's Hospital and the former Federated Dublin Voluntary Hospitals (now Tallaght or AMNiCH hospital), I developed clinical and research interests in the following areas: . PRIMARY IMMUNODEFICIENCY DISORDERS . AUTOIMMUNE DISORDERS, IN PARTICULAR CONNECTIVE TISSUE DISEASES . WEGENER'S GRANULOMATOSIS . COELIAC DISEASE. Since 1982, a busy clinical and laboratory Immunology service has evolved. The laboratory currently performs investigations on some 80,000 specimens per annum. A busy outpatient and daycare facility was established. In excess of 60 patients with primary immunodeficiency states attend the clinic and a home based therapy has been developed for patients with immunoglobulin deficiency states. Research has focused in particular on auto-immune disorders, with coeliac disease as the principal interest. However, research into other disorders including primary immunodeficiency states also continues.