Chunze Li

Department of Drug Metabolism and Pharmacokinetics Merck Research Laboratories

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论文共 11 篇作者统计合作学者相似作者

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Discovery of A Potent, Cns-Penetrant Orexin Receptor Antagonist Based on an N,N-Disubstituted-1,4-Diazepane Scaffold That Promotes Sleep in Rats

David B. Whitman,Christopher D. Cox, Michael J. Breslin,Karen M. Brashear,John D. Schreier,Michael J. Bogusky,Rodney A. Bednar,Wei Lemaire,Joseph G. Bruno,George D. Hartman,Duane R. Reiss,C. Meacham Harrell,Richard L. Kraus, Yuxing Li,Susan L. Garson,Scott M. Doran,Thomayant Prueksaritanont,Chunze Li,Christopher J. Winrow,Kenneth S. Koblan,John J. Renger,Paul J. Coleman

ChemMedChem（2009）

引用69浏览0WOS引用

IDENTIFICATION OF POTENT DUAL OREXIN RECEPTOR ANTAGONISTS

Paul J. Coleman,John D. Schreier,Christopher D. Cox,Michael J. Breslin,David B. Whitman,Anthony J. Roecker,Michael J. Bogusky,Rodney A. Bednar,Wei Lemaire,Joseph C. Bruno,George D. Hartman,Georgia B. McGaughey,Duane R. Reiss,C. Meacham Harrell,Scott M. Doran,Susan L. Garson,Richard L. Kraus, Yuxing Li,Thomayant Prueksaritanont,Chunze Li,Christopher J. Winrow,Kenneth S. Koblan,John J. Renger

DRUGS OF THE FUTUREno. SUPnan (2009): 10-11

引用0浏览0引用

Discovery Of Potent, Cns-Penetrant Dual Orexin Receptor Antagonists Containing A 1,4-Diazepane Central Constraint That Promotes Sleep In Rats

Christopher D. Cox,Michael J. Breslin,David B. Whitman,Karen M. Brashear,Anthony J. Roecker,Michael Bogusky,Rodney A. Bednar,Wei Lemaire, Joesph G. Bruno,George D. Hartman,Georgia Mcgaughey,Duane R. Reiss,C. Meacham Harrell,Scott M. Doran,Susan L. Garson,Richard L. Kraus, Yuxing Li,Thomayant Prueksaritanont,Chunze Li,Christopher J. Winrow,Ken S. Koblan,John J. Renger,Paul J. Coleman

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2009)

引用0浏览0引用

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Christopher D. Cox,Paul J. Coleman, Michael J. Breslin,David B. Whitman,Robert M. Garbaccio,Mark E. Fraley,Carolyn A. Buser,Eileen S. Walsh,Kelly Hamilton,Michael D. Schaber,Robert B. Lobell,Weikang Tao,Joseph P. Davide,Ronald E. Diehl,Marc T. Abrams,Vicki J. South,Hans E. Huber,Maricel Torrent,Thomayant Prueksaritanont,Chunze Li,Donald E. Slaughter,Elizabeth Mahan,Carmen Fernandez-Metzler,Youwei Yan,Lawrence C. Kuo,Nancy E. Kohl,George D. Hartman

JOURNAL OF MEDICINAL CHEMISTRY（2008）

引用143浏览0WOS引用

143

Proline Bis-Amides As Potent Dual Orexin Receptor Antagonists

Jeffrey M. Bergman,Anthony J. Roecker,Swati P. Mercer,Rodney A. Bednar,Duane R. Reiss,Richard W. Ransom,C. Meacham Harrell,Douglas J. Pettibone,Wei Lemaire,Kathy L. Murphy,Chunze Li,Thomayant Prueksaritanont,Christopher J. Winrow,John J. Renger,Kenneth S. Koblan,George D. Hartman,Paul J. Coleman

Bioorganic & Medicinal Chemistry Letters（2008）

引用78浏览0WOS引用

Kinesin Spindle Protein (KSP) Inhibitors. Part 7: Design and Synthesis of 3,3-Disubstituted Dihydropyrazolobenzoxazines As Potent Inhibitors of the Mitotic Kinesin KSP

Robert M. Garbaccio,Edward S. Tasbera,Lou Anne Neilson,Paul J. Coleman,Mark E. Fraley,Christy Olson, Jeff Bergman,Maricel Torrent,Carolyn A. Buser,Keith Rickert,Eileen S. Walsh,Kelly Hamilton,Robert B. Lobell,Weikang Tao,Vicki J. South,Ronald E. Diehl,Joseph P. Davide,Youwei Yan,Lawrence C. Kuo,Chunze Li,Thomayant Prueksaritanont,Carmen Fernandez-Metzler,Elizabeth A. Mahan,Donald E. Slaughter,Joseph J. Salata,Nancy E. Kohl,Hans E. Huber,George D. Hartman

ChemInform（2008）

引用22浏览0WOS引用

Medi 320-Proline Bis-Amides As Potent Dual Orexin Receptor Antagonists With In Vivo Efficacy

Anthony J. Roecker,Jeffrey M. Bergman,Swati P. Mercer,Christopher D. Cox,Michael J. Breslin,David B. Whitman, Kevin B. Albertson,Scott M. Doran,Christopher J. Winrow,Susan L. Garson,Steve V. Fox,C. Meacham Harrell,Duane R. Reiss, Kristi Hoffman,Kenneth D. Anderson,Rodney A. Bednar,Wei Lemaire,Kathy L. Murphy,Elizabeth Mahan, Julia Qiu,Chunze Li,Thomayant Prueksaritanont,Ken S. Koblan,George D. Hartman,John J. Renger,Paul J. Coleman

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（2008）

引用0浏览0引用

Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP

Paul J. Coleman,John D. Schreier,Christopher D. Cox,Mark E. Fraley,Robert M. Garbaccio,Carolyn A. Buser,Eileen S. Walsh,Kelly Hamilton,Robert B. Lobell,Keith Rickert,Weikang Tao,Ronald E. Diehl,Vicki J. South,Joseph P. Davide,Nancy E. Kohl,Youwei Yan,Lawrence Kuo,Thomayant Prueksaritanont,Chunze Li,Elizabeth A. Mahan,Carmen Fernandez-Metzler,Joseph J. Salata,George D. Hartman

Bioorganic & Medicinal Chemistry Letters（2007）

引用32浏览0EIWOS引用

Kinesin Spindle Protein (KSP) Inhibitors. Part 4: Structure-based Design of 5-Alkylamino-3,5-diaryl-4,5-dihydropyrazoles As Potent, Water-Soluble Inhibitors of the Mitotic Kinesin KSP

CD Cox,M Torrent,MJ Breslin,BJ Mariano,DB Whitman,PJ Coleman,CA Buser,ES Walsh,K Hamilton,MD Schaber,RB Lobell,WK Tao,VJ South,NE Kohl,YW Yan,LC Kuo,T Prueksaritanont,DE Slaughter,CZ Li,E Mahan,B Lu,GD Hartman

Bioorganic & Medicinal Chemistry Letters（2006）

引用75浏览0WOS引用

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作者统计

#Papers: 11

#Citation: 508

H-Index: 8

G-Index: 8

Sociability: 4

Diversity: 2

Activity: 0

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