基本信息
浏览量:4
职业迁徙
个人简介
Research synopsis
Cell growth and integrity require membrane growth and integrity. We are using cross-disciplinary approaches to elucidate vital roles of inter-organelle contacts in membrane biogenesis and homeostasis at the molecular, ultra-structural, cellular, and tissue levels. Inter-organelle contacts serve as key sites for the coordinated regulation of membrane lipid metabolism and transport. Our studies have focused on contacts between the endoplasmic reticulum and the plasma membrane (ER-PM contacts), providing new understanding of membrane lipid and calcium dynamics during regulated exocytosis and polarised secretion. We are currently examining ER-PM contact architecture and function in hepatocytes, polarised epithelial cells of the liver. These investigations are suggesting new strategies to control biliary secretion that may prove beneficial in the treatment of liver disease.
Furthermore, we are probing how alterations in inter-organelle contacts and membrane lipid homeostasis result in organelle damage. These studies are revealing novel protective pathways that sense and respond to membrane stress conditions to ensure membrane integrity and organelle homeostasis. Numerous diseases are caused by imbalances in membrane lipid homeostasis including cancer, diabetes, and neurodegenerative disorders. We expect our investigations will identify new targets and strategies for the treatment of diseases caused by disruptions in membrane lipid and organelle homeostasis.
Cell growth and integrity require membrane growth and integrity. We are using cross-disciplinary approaches to elucidate vital roles of inter-organelle contacts in membrane biogenesis and homeostasis at the molecular, ultra-structural, cellular, and tissue levels. Inter-organelle contacts serve as key sites for the coordinated regulation of membrane lipid metabolism and transport. Our studies have focused on contacts between the endoplasmic reticulum and the plasma membrane (ER-PM contacts), providing new understanding of membrane lipid and calcium dynamics during regulated exocytosis and polarised secretion. We are currently examining ER-PM contact architecture and function in hepatocytes, polarised epithelial cells of the liver. These investigations are suggesting new strategies to control biliary secretion that may prove beneficial in the treatment of liver disease.
Furthermore, we are probing how alterations in inter-organelle contacts and membrane lipid homeostasis result in organelle damage. These studies are revealing novel protective pathways that sense and respond to membrane stress conditions to ensure membrane integrity and organelle homeostasis. Numerous diseases are caused by imbalances in membrane lipid homeostasis including cancer, diabetes, and neurodegenerative disorders. We expect our investigations will identify new targets and strategies for the treatment of diseases caused by disruptions in membrane lipid and organelle homeostasis.
研究兴趣
论文共 110 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Scientific reportsno. 1 (2024)
Christopher K Cote,Kevin D Mlynek,Christopher P Klimko,Sergei S Biryukov,Sherry Mou,Melissa Hunter,Nathaniel O Rill,Jennifer L Dankmeyer, Jeremey A Miller,Yuli Talyansky,Michael L Davies,J Matthew Meinig,Stephanie A Halasohoris, Anette M Gray, Jade L Spencer,Ashley L Babyak, M Kelly Hourihan, Bobby J Curry,Ronald G Toothman,Sara I Ruiz, Xiankun Zeng,Keersten M Ricks,Tamara L Clements,Christina E Douglas, Suma Ravulapalli,Christopher P Stefan,Charles J Shoemaker,Mindy G Elrod,Jay E Gee,Zachary P Weiner,Ju Qiu,Joel A Bozue,Nancy A Twenhafel,David DeShazer
Emerging infectious diseasesno. 10 (2024): 2056-2069
Christopher Stefan, Roberto Covino
The Journal of cell biologyno. 11 (2024)
Ian Davis, Jackie M. Payne,Victoria L. Olguin, Madison P. Sanders,Tamara Clements,Christopher P. Stefan,Janice A. Williams,Jay W. Hooper,John W. Huggins,Eric M. Mucker,Keersten M. Ricks
Frontiers in microbiology (2023)
Yu Cong,Eric M. Mucker,Donna L. Perry,Saurabh Dixit,Erin Kollins,Russ Byrum,Louis Huzella,Robert Kim, Mathew Josleyn,Steven Kwilas,Christopher Stefan,Charles J. Shoemaker, Jeff Koehler,Susan Coyne,Korey Delp,Janie Liang,David Drawbaugh,Amanda Hischak,Randy Hart,Elena Postnikova, Nick Vaughan, Jason Asher,Marisa St Claire, Jarod Hanson,Connie Schmaljohn,Ann E. Eakin,Jay W. Hooper,Michael R. Holbrook
Sandra L. Bixler,Christopher P. Stefan,Alexandra N. Jay,Franco D. Rossi,Keersten M. Ricks,Charles J. Shoemaker,Alicia M. Moreau,Xiankun Zeng,Jay W. Hooper,David N. Dyer,Ondraya M. Frick,Jeffrey W. Koehler,Brian J. Kearney,Nina DiPinto,Jun Liu,Samantha D. Tostenson,Tamara L. Clements,Jeffrey M. Smith,Joshua A. Johnson,Kerry L. Berrier,Heather L. Esham,Korey L. Delp,Susan R. Coyne,Holly A. Bloomfield,Paul A. Kuehnert,Kristen Akers,Kathleen M. Gibson,Timothy D. Minogue,Aysegul Nalca,Margaret L. M. Pitt
加载更多
作者统计
#Papers: 113
#Citation: 4995
H-Index: 31
G-Index: 70
Sociability: 6
Diversity: 3
Activity: 50
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn