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职业迁徙
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Research synopsis
Cell growth and integrity require membrane growth and integrity. We are using cross-disciplinary approaches to elucidate vital roles of inter-organelle contacts in membrane biogenesis and homeostasis at the molecular, ultra-structural, cellular, and tissue levels. Inter-organelle contacts serve as key sites for the coordinated regulation of membrane lipid metabolism and transport. Our studies have focused on contacts between the endoplasmic reticulum and the plasma membrane (ER-PM contacts), providing new understanding of membrane lipid and calcium dynamics during regulated exocytosis and polarised secretion. We are currently examining ER-PM contact architecture and function in hepatocytes, polarised epithelial cells of the liver. These investigations are suggesting new strategies to control biliary secretion that may prove beneficial in the treatment of liver disease.
Furthermore, we are probing how alterations in inter-organelle contacts and membrane lipid homeostasis result in organelle damage. These studies are revealing novel protective pathways that sense and respond to membrane stress conditions to ensure membrane integrity and organelle homeostasis. Numerous diseases are caused by imbalances in membrane lipid homeostasis including cancer, diabetes, and neurodegenerative disorders. We expect our investigations will identify new targets and strategies for the treatment of diseases caused by disruptions in membrane lipid and organelle homeostasis.
Cell growth and integrity require membrane growth and integrity. We are using cross-disciplinary approaches to elucidate vital roles of inter-organelle contacts in membrane biogenesis and homeostasis at the molecular, ultra-structural, cellular, and tissue levels. Inter-organelle contacts serve as key sites for the coordinated regulation of membrane lipid metabolism and transport. Our studies have focused on contacts between the endoplasmic reticulum and the plasma membrane (ER-PM contacts), providing new understanding of membrane lipid and calcium dynamics during regulated exocytosis and polarised secretion. We are currently examining ER-PM contact architecture and function in hepatocytes, polarised epithelial cells of the liver. These investigations are suggesting new strategies to control biliary secretion that may prove beneficial in the treatment of liver disease.
Furthermore, we are probing how alterations in inter-organelle contacts and membrane lipid homeostasis result in organelle damage. These studies are revealing novel protective pathways that sense and respond to membrane stress conditions to ensure membrane integrity and organelle homeostasis. Numerous diseases are caused by imbalances in membrane lipid homeostasis including cancer, diabetes, and neurodegenerative disorders. We expect our investigations will identify new targets and strategies for the treatment of diseases caused by disruptions in membrane lipid and organelle homeostasis.
研究兴趣
论文共 110 篇作者统计合作学者相似作者
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SCIENTIFIC REPORTSno. 1 (2024)
Christopher K Cote,Kevin D Mlynek,Christopher P Klimko,Sergei S Biryukov,Sherry Mou,Melissa Hunter,Nathaniel O Rill,Jennifer L Dankmeyer, Jeremey A Miller,Yuli Talyansky,Michael L Davies,J Matthew Meinig,Stephanie A Halasohoris, Anette M Gray, Jade L Spencer,Ashley L Babyak, M Kelly Hourihan, Bobby J Curry,Ronald G Toothman,Sara I Ruiz, Xiankun Zeng,Keersten M Ricks,Tamara L Clements,Christina E Douglas, Suma Ravulapalli,Christopher P Stefan,Charles J Shoemaker,Mindy G Elrod,Jay E Gee,Zachary P Weiner,Ju Qiu,Joel A Bozue,Nancy A Twenhafel,David DeShazer
Emerging infectious diseasesno. 10 (2024): 2056-2069
Christopher Stefan, Roberto Covino
The Journal of cell biologyno. 11 (2024)
Ian Davis, Jackie M. Payne,Victoria L. Olguin, Madison P. Sanders,Tamara Clements,Christopher P. Stefan,Janice A. Williams,Jay W. Hooper,John W. Huggins,Eric M. Mucker,Keersten M. Ricks
Frontiers in microbiology (2023)
Yu Cong,Eric M. Mucker,Donna L. Perry,Saurabh Dixit,Erin Kollins,Russ Byrum,Louis Huzella,Robert Kim, Mathew Josleyn,Steven Kwilas,Christopher Stefan,Charles J. Shoemaker, Jeff Koehler,Susan Coyne,Korey Delp,Janie Liang,David Drawbaugh,Amanda Hischak,Randy Hart,Elena Postnikova, Nick Vaughan, Jason Asher,Marisa St Claire, Jarod Hanson,Connie Schmaljohn,Ann E. Eakin,Jay W. Hooper,Michael R. Holbrook
Sandra L. Bixler,Christopher P. Stefan,Alexandra N. Jay,Franco D. Rossi,Keersten M. Ricks,Charles J. Shoemaker,Alicia M. Moreau,Xiankun Zeng,Jay W. Hooper,David N. Dyer,Ondraya M. Frick,Jeffrey W. Koehler,Brian J. Kearney,Nina DiPinto,Jun Liu,Samantha D. Tostenson,Tamara L. Clements,Jeffrey M. Smith,Joshua A. Johnson,Kerry L. Berrier,Heather L. Esham,Korey L. Delp,Susan R. Coyne,Holly A. Bloomfield,Paul A. Kuehnert,Kristen Akers,Kathleen M. Gibson,Timothy D. Minogue,Aysegul Nalca,Margaret L. M. Pitt
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作者统计
#Papers: 110
#Citation: 4964
H-Index: 31
G-Index: 70
Sociability: 6
Diversity: 3
Activity: 49
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