Metallo’s work focuses on mapping these interconnected metabolic networks to uncover disease-causing pathways. Using tracer molecules and advanced mass spectroscopy techniques, his lab identifies how molecules are broken down and re-built, where metabolites end up in the body, and what regulates these processes. Taking this approach, Metallo has made key discoveries about the metabolic pathways that drive cancer progression and macular disease-pathways, which can then be influenced through dietary manipulations or targeted therapies.