基本信息
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职业迁徙
个人简介
AREAS OF INTEREST
Adolescent brain plasticity, individual differences in vulnerability and resilience to mental illnesses, including eating disorders and anxiety, neural circuits, synaptic molecules, electron microscopy.
RESEARCH OVERVIEW
The long-term goal of my research has been to understand the cell biological mechanisms underlying plasticity and stability of neurons. The mammalian brain undergoes dramatic developmental changes after birth, yielding neural functions that reflect the experience of early life. Once mature, the pathways of the brain become more stable while maintaining a certain degree of plasticity. I have learned that this developmental process is prolonged into adolescence for brain regions that are highly associational, such as the prefrontal cortex and hippocampus.
Currently, I am most interested in understanding the cellular bases of resilience gained when adolescent individuals are placed in stressful environments. I am focusing my research on plasticity of synaptic circuits within the prefrontal cortex and hippocampus, using the paradigm of food restriction-evoked stress which elicits excessive exercise and severe body weight loss in rodents, much as is seen among patients diagnosed with anorexia nervosa. The approach of analyzing synaptic properties in these brain regions across individuals with varying degrees of resilience has shown interesting correlates, providing clues about molecules within circuits that influence maladaptive behavior and resilience. I take these clues to interrogate the circuits and molecules involved in the generation of maladaptive behavior, using knockdown and knockout of genes, pharmacology and chemogenetic modulations. I am also exploring the synaptic mechanisms underlying the ameliorative properties of sub-anesthetic doses of ketamine against anorexia-like maladaptive behaviors.
Adolescent brain plasticity, individual differences in vulnerability and resilience to mental illnesses, including eating disorders and anxiety, neural circuits, synaptic molecules, electron microscopy.
RESEARCH OVERVIEW
The long-term goal of my research has been to understand the cell biological mechanisms underlying plasticity and stability of neurons. The mammalian brain undergoes dramatic developmental changes after birth, yielding neural functions that reflect the experience of early life. Once mature, the pathways of the brain become more stable while maintaining a certain degree of plasticity. I have learned that this developmental process is prolonged into adolescence for brain regions that are highly associational, such as the prefrontal cortex and hippocampus.
Currently, I am most interested in understanding the cellular bases of resilience gained when adolescent individuals are placed in stressful environments. I am focusing my research on plasticity of synaptic circuits within the prefrontal cortex and hippocampus, using the paradigm of food restriction-evoked stress which elicits excessive exercise and severe body weight loss in rodents, much as is seen among patients diagnosed with anorexia nervosa. The approach of analyzing synaptic properties in these brain regions across individuals with varying degrees of resilience has shown interesting correlates, providing clues about molecules within circuits that influence maladaptive behavior and resilience. I take these clues to interrogate the circuits and molecules involved in the generation of maladaptive behavior, using knockdown and knockout of genes, pharmacology and chemogenetic modulations. I am also exploring the synaptic mechanisms underlying the ameliorative properties of sub-anesthetic doses of ketamine against anorexia-like maladaptive behaviors.
研究兴趣
论文共 171 篇作者统计合作学者相似作者
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引用量
主题
期刊级别
合作者
合作机构
INTERNATIONAL JOURNAL OF EATING DISORDERSno. 7 (2024): 1447-1464
Cell reportsno. 3 (2024): 113834-113834
Research Square (Research Square) (2023)
BRAIN STRUCTURE & FUNCTIONno. 6 (2022): 2127-2151
Frontiers in behavioral neuroscience (2022)
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作者统计
#Papers: 171
#Citation: 10790
H-Index: 53
G-Index: 101
Sociability: 6
Diversity: 0
Activity: 1
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