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个人简介
Dr. Lu's laboratory(link is external and opens in a new window) is interested in understanding basic mechanisms governing chromatin organization and access during normal and cancer development. Eukaryotic cells develop sophisticated mechanisms to package and access their genetic information, and recent studies uncover that proteins involved in genome regulation are frequently altered in human developmental disorders and cancers. These findings raise the questions of whether and how aberrant chromatin landscape facilitates human disease development. Our previous work have largely focused on hotspot, gain-of-function mutations in chromatin modulators and regulators, including IDH1/2 and histone H3, that are frequently identified in a number of adult and pediatric cancer types. Collectively we have delineated the biochemical mechanisms by which these mutations alter global chromatin landscape. We also demonstrated that chromatin mutations are pro-oncogenic through blockade of cellular differentiation. These findings provide compelling evidence for a causal role of chromatin dysregulation in oncogenesis, and propose a novel pathway of cancer initiation through accumulation of hyper-proliferative and differentiation-refractory tissue progenitor cells driven by epigenome abnormality.
研究兴趣
论文共 120 篇作者统计合作学者相似作者
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Elsevier eBookspp.239-256, (2024)
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Kristjan H Gretarsson,Stephen Abini-Agbomson,Susan L Gloor,Daniel N Weinberg, Jamie L McCuiston, Vishnu Udayakumar Sunitha Kumary,Allison R Hickman,Varun Sahu,Rachel Lee,Xinjing Xu, Natalie Lipieta,Samuel Flashner, Oluwatobi A Adeleke,Irina K Popova,Hailey F Taylor,Kelsey Noll, Carolina Lin Windham,Danielle N Maryanski,Bryan J Venters,Hiroshi Nakagawa,Michael-Christopher Keogh,Karim-Jean Armache,Chao Lu
Science Advancesno. 35 (2024)
CELL REPORTSno. 1 (2024)
Giuseppe Leuzzi,Alessandro Vasciaveo,Angelo Taglialatela, Xiao Chen, Tessa M. Firestone,Allison R. Hickman,Wendy Mao,Tanay Thakar,Alina Vaitsiankova,Jen-Wei Huang,Raquel Cuella-Martin,Samuel B. Hayward,Jordan S. Kesner,Ali Ghasemzadeh,Tarun S. Nambiar,Patricia Ho,Alexander Rialdi,Maxime Hebrard,Yinglu Li, Jinmei Gao,Saarang Gopinath, Oluwatobi A. Adeleke,Bryan J. Venters,Charles G. Drake,Richard Baer,Benjamin Izar,Ernesto Guccione,Michael-Christopher Keogh,Raphael Guerois,Lu Sun,Chao Lu,Andrea Califano,Alberto Ciccia
Cellno. 4 (2024): 861-881.e32
Sakina A. Plumber,Tiffany Tate,Hikmat Al-Ahmadie,Xiao Chen,Woonyoung Choi, Merve Basar,Chao Lu,Aaron Viny,Ekatherina Batourina, Jiaqi Li,Kristjan Gretarsson, Besmira Alija,Andrei Molotkov,Gregory Wiessner,Byron Hing Lung Lee,James McKiernan,David J. McConkey,Colin Dinney,Bogdan Czerniak,Cathy Lee Mendelsohn
NATURE COMMUNICATIONSno. 1 (2024)
Albert M. Li,Bo He, Dimitris Karagiannis,Yang Li,Haowen Jiang, Preethi Srinivasan, Yaniel Ramirez, Meng-Ning Zhou, Christina Curtis,Joshua J. Gruber,Chao Lu,Erinn B. Rankin,Jiangbin Ye
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 38 (2023)
Jonathan F Thomas,Marco Igor Valencia-Sánchez,Simone Tamburri,Susan L Gloor, Samantha Rustichelli, Victoria Godínez-López,Pablo De Ioannes, Rachel Lee,Stephen Abini-Agbomson, Kristjan Gretarsson,Jonathan M Burg,Allison R Hickman,Lu Sun, Saarang Gopinath, Hailey Taylor,Matthew J Meiners,Marcus A Cheek,William Rice,Evgeny Nudler,Chao Lu,Michael-Christopher Keogh,Diego Pasini,Karim-Jean Armache
bioRxiv the preprint server for biology (2023)
Natureno. 7987 (2023): 643-651
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作者统计
#Papers: 119
#Citation: 14615
H-Index: 40
G-Index: 81
Sociability: 7
Diversity: 3
Activity: 223
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