Catherine O'Brien

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个人简介

The focus of Dr O’Brien’s lab is to identify the molecular pathways responsible for driving tumour growth in colorectal cancer.

The ultimate goal being to utilize this knowledge to devise improved therapeutic strategies for colorectal cancer.

研究兴趣

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In Vivo CRISPR Screens Identify a Dual Function of MEN1 in Regulating Tumor-Microenvironment Interactions

Peiran Su,Yin Liu, Tianyi Chen, Yibo Xue, Yong Zeng,Guanghui Zhu,Sujun Chen,Mona Teng,Xinpei Ci,Mengdi Guo,Michael Y. He, Jun Hao, Vivian Chu,Wenxi Xu,Shiyan Wang,Parinaz Mehdipour,Xin Xu,Sajid A. Marhon,Fraser Soares,Nhu-An Pham, Bell Xi Wu, Peter Hyunwuk Her,Shengrui Feng,Najd Alshamlan, Maryam Khalil,Rehna Krishnan,Fangyou Yu,Chang Chen,Francis Burrows,Razqallah Hakem,Mathieu Lupien,Shane Harding,Benjamin H. Lok,Catherine O'Brien,Alejandro Berlin,Daniel D. De Carvalho,David G. Brooks,Daniel Schramek,Ming-Sound Tsao,Housheng Hansen He

NATURE GENETICS (2024)

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18F-Fluoroazomycin Arabinoside (FAZA) PET/MR As a Biomarker of Hypoxia in Rectal Cancer: A Pilot Study

Ur Metser,Andres Kohan,Catherine O'Brien,Rebecca K S Wong,Claudia Ortega,Patrick Veit-Haibach,Brandon Driscoll,Ivan Yeung,Adam Farag

Tomographyno. 9 (2024): 1354-1364

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Figure S1-S6 from Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer

Jennifer Haynes,Trevor D. McKee,Andrew Haller, Yadong Wang,Cherry Leung,Deena M.A. Gendoo,Evelyne Lima-Fernandes,Antonija Kreso, Robin Wolman,Eva Szentgyorgyi,Douglass C. Vines,Benjamin Haibe-Kains,Bradly G. Wouters,Ur Metser,David A. Jaffray,Myles Smith,Catherine A. O'Brien

openalex（2023）

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AML Drug Tolerant Persister (DTP) Cells Survive Chemotherapy by Transiently Altering Cellular Lipidomics to Increase Plasma Membrane Rigidity, but Also Increases Sensitivity to Immune Cell Killing

Yael Morgenstern,JongBok Lee,Yoosu Na,William Gwynne,Rose Hurren, Li Ma,Marcela Gronda,Chaitra Sarathy, Arvind Mer,Andrea Arruda,Avraham Frisch,Tsila Zuckerman,Yishai Ofran,Mark D. Minden,Li Zhang,Catherine O'Brien,J. Rafael Montenegro-Burke,Aaron D. Schimmer

Bloodno. Supplement 1 (2023): 2806-2806

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Supplementary Data from Prostate Cancer–Associated Gene Expression Alterations Determined from Needle Biopsies

David Z. Qian,Chung‐Ying Huang,Catherine A. O’Brien,Ilsa M. Coleman, Mark Garzotto,Lawrence D. True,Celestia S. Higano, Robert L. Vessella, Paul H. Lange,Peter S. Nelson,Tomasz M. Beer

openalex

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Supplementary Materials and Methods from Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer

Jennifer Haynes,Trevor D. McKee,Andrew Haller,Yadong Wang, C.W. Leung,Deena M.A. Gendoo,Evelyne Lima‐Fernandes,Antonija Kreso, Robin Wolman,Eva Szentgyörgyi,Douglass Vines,Benjamin Haibe‐Kains, Bradly G. Wouters,Ur Metser, D. Jaffray,Myles Smith,Catherine A. O’Brien

openalex（2023）

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Persister Cells That Survive Chemotherapy Are Pinpointed

Sumaiyah K. Rehman,Catherine A. O’Brien

Nature（2022）

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CRISPR Screens Identify Cholesterol Biosynthesis As a Therapeutic Target on Stemness and Drug Resistance of Colon Cancer

Shanshan Gao,Fraser Soares,Shiyan Wang,Chi Chun Wong,Huarong Chen,Zhenjie Yang,Weixin Liu,Minnie Y. Y. Go,Musaddeque Ahmed,Yong Zeng,Catherine Adell O’Brien,Joseph J. Y. Sung,Housheng Hansen He,Jun Yu

Oncogene（2021）

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论文共 73 篇作者统计合作学者相似作者