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Introduction – Ubiquinone (coenzyme Q or Q) functions in cells as a redox-active coenzyme of mitochondrial and plasma membrane electron transport, as well as an essential lipid soluble antioxidant. Human dietary supplementation with Q appears to have beneficial effects in slowing the progression of neuro- and muscle-degenerative diseases. However, Q is also involved in generating reactive oxygen species, through the adventitious reduction of dioxygen to superoxide by the ubisemiquinone radical, normally generated during mitochondrial electron transport. Thus, it is not clear how dietary supplementation with Q impacts the Dr. Jekyll/Mr. Hyde aspects of Q function. Cells are capable of synthesizing Q, but much remains to be learned about the sites of its synthesis, mechanisms of inter- and intra-cellular transport, and the regulation and enzymology of its biosynthesis. Research in my laboratory identified eight of the eleven polypeptides required for Q biosynthesis. The goals of my research are to characterize the Coq polypeptides responsible for production of Q and to determine how their activity can be modulated for optimal health.
Specialties
Aging and Development
Biochemistry
Chemical Biology
Metabolism
Proteomics and Bioinformatics
Systems Biology and Biological Regulation
Introduction – Ubiquinone (coenzyme Q or Q) functions in cells as a redox-active coenzyme of mitochondrial and plasma membrane electron transport, as well as an essential lipid soluble antioxidant. Human dietary supplementation with Q appears to have beneficial effects in slowing the progression of neuro- and muscle-degenerative diseases. However, Q is also involved in generating reactive oxygen species, through the adventitious reduction of dioxygen to superoxide by the ubisemiquinone radical, normally generated during mitochondrial electron transport. Thus, it is not clear how dietary supplementation with Q impacts the Dr. Jekyll/Mr. Hyde aspects of Q function. Cells are capable of synthesizing Q, but much remains to be learned about the sites of its synthesis, mechanisms of inter- and intra-cellular transport, and the regulation and enzymology of its biosynthesis. Research in my laboratory identified eight of the eleven polypeptides required for Q biosynthesis. The goals of my research are to characterize the Coq polypeptides responsible for production of Q and to determine how their activity can be modulated for optimal health.
Specialties
Aging and Development
Biochemistry
Chemical Biology
Metabolism
Proteomics and Bioinformatics
Systems Biology and Biological Regulation
研究兴趣
论文共 238 篇作者统计合作学者相似作者
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The Journal of biological chemistrypp.107820-107820, (2024)
Kelsey J. Feustel,Catherine F. Clarke
Nature Catalysisno. 2 (2024): 117-119
Journal of Biological Chemistryno. 3 (2023)
Antioxidantsno. 7 (2023): 1391
JOURNAL OF BIOLOGICAL CHEMISTRYno. 3 (2023): S354-S354
Anita Ayer,Daniel J. Fazakerley,Cacang Suarna,Ghassan J. Maghzal,Diba Sheipouri, Kevin J. Lee,Michelle C. Bradley,Lucia Fernandez-del-Rio,Sergey Tumanov,Stephanie My Kong,Jelske N. van der Veen,Andrian Yang,Joshua W. K. Ho,Steven G. Clarke,David E. James,Ian W. Dawes,Dennis E. Vance,Catherine F. Clarke,Rene L. Jacobs,Roland Stocker
Redox biology (2021): 102127-102127
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#Papers: 236
#Citation: 10418
H-Index: 56
G-Index: 98
Sociability: 7
Diversity: 0
Activity: 0
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