Microbes are exquisite architects of both host physiology and the world around us. Research in my lab aims to comprehensively identify the molecular pathways that govern host-microbial interactions to influence host health. To this end, we have developed the high-throughput amenable and robust model C. elegans as a both a natural and translational system for microbiome research. We have leveraged this system to identify conserved genetic circuits that can be used to manage microbiome influence.