The maintenance of genetic integrity is a fundamental problem for all dividing cells. Abnormal chromosome segregation in the form of trisomies such as Down's syndrome occurs in 25% of aborted human fetuses and 0.3% of newborns. In addition, aberrant chromosome transmission is a hallmark of cancer cells and significantly enhances the progression of many tumours. My lab studies the molecular mechanisms of eukaryotic chromosome transmission using budding yeast as a model organism.