Her primary interests are developing and investigating novel pain treatments that are scalable, effective, and low burden. She is creator of "Empowered Relief", a single-session evidence based pain management intervention, and principal investigator for a 6-site $11M national randomized comparative effectiveness trial of online "Empowered Relief" vs. online 8-session cognitive behavioral therapy in diverse patients and pain conditions in the U.S. (funded by PCORI; 2022-2027). She and her team provide international clinician certification workshops for "Empowered Relief" (https://empoweredrelief.stanford.edu/). "Empowered Relief" is delivered in 16 countries, 7 languages, and is the subject of international research. In 2021, results for an NIH-funded randomized trial of "Empowered Relief" published in JAMA Network Open. Also in 2021 a second randomized trial of online-received "Empowered Relief" showed efficacy in mixed-etiology chronic pain 3 months after treatment (Ziadni et al). Digital analgesic innovations include on-demand, skills-based, self-regulatory treatment for perioperative patients (“My Surgical Success”, showing extended pain relief 3 months after surgery (Ziadni et al, 2022), and virtual reality for acute and chronic pain (she is chief science advisor at AppliedVR). The broad goal of this collective line of research is to dismantle barriers to effective behavioral medicine for pain and health.