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In our lab, we focus in particular on integrin- and cadherin-mediated adhesions, and study the mechanisms whereby they sense external surfaces, recognizing not only their chemical composition, but also their physical properties, including their topography, rigidity and ligand density. Systematic molecular modulation of the adhesion sites is used in an attempt to decipher the mechanisms whereby the adhesion-based molecular machinery integrates complex environmental information and triggers a coherent and robust response. Specifically, we combine a wide variety of molecular perturbation approaches with advanced, quantitative imaging technologies, to study cancer cell invasion and migration, osteoclast-mediated bone remodeling, platelet adhesion and activation, the formation and maintenance of the epithelial barrier function in the gut, the development of antigen-specific stimulatory surfaces that stimulate T-lymphocytes, and more.
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biorxiv(2024)
Minhua Su, Tom Fleisher,Inna Grosheva,Melanie Bokstad Horev,Malgorzata Olszewska,Camilla Ciolli Mattioli,Haim Barr,Alexander Plotnikov,Silvia Carvalho, Yoni Moskovich,Mark D. Minden, Noa Chapal-Ilani,
iScienceno. 4 (2024): 109443-109443
Biomoleculesno. 2 (2023): 294-294
Frontiers in oncology (2023): 1116328-1116328
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