My research focuses on T cell antigen recognition and how it determines T cell responses. I use ultrasensitive two-dimensional (2D) methods to analyze T cell antigen recognition by measuring 2D kinetics of T cell receptor (TCR) and coreceptor (CD4/8) interacting with pMHC on live T cells at the single molecule/single cell level. I am currently working on a project looking at how diabetogenic CD8 T cells recognize beta-cell self-antigens and how 2D kinetics parameters correlate with type I diabetes. I am generally interested in the application of 2D methods to further our understanding of T cell antigen recognition in the broad context of viral infection, autoimmune diseases, and tumor immunology.