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Research Summary
The Laboratory of Molecular Hermeneutics is interested in how cells regulate their intracellular calcium concentration. Cells use changes in calcium as a trigger for many cellular events, including cell growth, secretion, contraction, and neurotransmission. We have focused on one aspect of this process, the release of calcium from intracellular stores. We use calcium imaging combined with electrophysiological, biochemical, and molecular techniques to study the classes of calcium release channels known to exist inside virtually all cells: the InsP3-gated channel, the ryanodine receptor, and polycystin-2. Our first goal is to understand the basic question: how is the function of these channels regulated. Our second goal is to use the answers to the first question to understand the loss of calcium regulation observed in disease states as seen in cells from patients with polycystic kidney disease or leading to drug-induced neuropathy. We hypothesize that these abnormalities in function are consequences, at least in part, of altered intracellular calcium homeostasis and that our studies will lead to suitable treatment regimens.
Specialized Terms: Intracellular calcium regulation
Research Interests
Calcium; Polycystic Kidney Diseases; Pharmacology; Physiology; Hermeneutics
The Laboratory of Molecular Hermeneutics is interested in how cells regulate their intracellular calcium concentration. Cells use changes in calcium as a trigger for many cellular events, including cell growth, secretion, contraction, and neurotransmission. We have focused on one aspect of this process, the release of calcium from intracellular stores. We use calcium imaging combined with electrophysiological, biochemical, and molecular techniques to study the classes of calcium release channels known to exist inside virtually all cells: the InsP3-gated channel, the ryanodine receptor, and polycystin-2. Our first goal is to understand the basic question: how is the function of these channels regulated. Our second goal is to use the answers to the first question to understand the loss of calcium regulation observed in disease states as seen in cells from patients with polycystic kidney disease or leading to drug-induced neuropathy. We hypothesize that these abnormalities in function are consequences, at least in part, of altered intracellular calcium homeostasis and that our studies will lead to suitable treatment regimens.
Specialized Terms: Intracellular calcium regulation
Research Interests
Calcium; Polycystic Kidney Diseases; Pharmacology; Physiology; Hermeneutics
研究兴趣
论文共 233 篇作者统计合作学者相似作者
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期刊级别
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The Journal of clinical investigation/The journal of clinical investigation (2024)
Journal of Physiology and Biochemistrypp.1-13, (2024)
openalex(2023)
bioRxiv : the preprint server for biology (2023)
Supportive Care in Cancer (2023): 1-2
Frontiers in pain research (2022)
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作者统计
#Papers: 236
#Citation: 15604
H-Index: 61
G-Index: 122
Sociability: 7
Diversity: 4
Activity: 40
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