He led several NIH-funded randomized controlled trials of pharmacologic and non-pharmacologic interventions to improve patient outcomes related to a number of complex topics, including hemodialysis leg cramps, nutritional status in renal failure, phosphorus intake among dialysis patients, adequacy of dialysis, and access to kidney transplantation. He recently completed studies that i) utilized navigators to enhance access to transplantation and ii) determined the impact of directly observed fluoxetine treatment for depression in hemodialysis patients.