Dr. Rajan’s clinical research related to drug development for thymic cancers is well recognized. He has conducted numerous clinical trials evaluating various biological therapies including insulin-like growth factor receptor inhibitors (cixutumumab), histone deacetylase inhibitors (belinostat), and multikinase inhibitors (sunitinib). Dr. Rajan and his group have studied the expression of the cell surface glycoprotein, mesothelin in thymic carcinoma. Based on this work, an ongoing clinical trial is evaluating the mesothelin-directed, antibody-drug conjugate, anetumab in patients with advanced thymic carcinoma.