George N. Pavlakis

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RESEARCH SUMMARY
The Human Retrovirus Section designed, developed and tested vaccines and immunotherapies for AIDS and cancer. We developed and tested new technologies including nucleic acid delivery methods in vivo, prophylactic and therapeutic vaccines and immunotherapies. We studied the role and application of cytokines in vaccines and cancer immunotherapy.

The Human Retrovirus Section focused on the development of innovative vaccines and immunotherapies for AIDS and cancer based on the understanding of basic mechanisms, and by combining our expertise in molecular biology, virology and immunology.

Research Interests

Papers共 598 篇Author StatisticsCo-AuthorSimilar Experts

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Abstract 4064: hetIL-15 and Fenofibrate combination alters the metabolic fitness of tumor-infiltrating CD8+T cells leading to TNBC tumor eradication in mice

Dimitris Stellas,Sevasti Karaliota,Vasiliki Stravokefalou,Katherine C. Goldfarbmuren,Breana Myers,George N. Pavlakis, Barbara K. Felber

Cancer Research（2024）

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Focusing HIV-1 Gag T-cell Responses to Highly Conserved Regions by DNA Vaccination in HVTN 119

Spyros A. Kalams,Barbara K. Felber,James I. Mullins,Hyman M. Scott,Mary A. Allen,Stephen C. De Rosa,Jack Heptinstall,Georgia D. Tomaras, Jiani Hu,Allan C. DeCamp,Margherita Rosati,Jenifer Bear,Michael N. Pensiero,John Eldridge,Michael A. Egan,Drew Hannaman, M. Juliana McElrath,George N. Pavlakis

JCI INSIGHTno. 18 (2024)

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Novel Highly Immunogenic DNA Vaccine Regimen Potently Activates Lymph Nodes in Macaques

Barbara Felber, Maha Moussa, Sevasti Karaliota,Margherita Rosati, Santhi Devasundaram, Katherine Goldfarbmuren, Jenifer Bear, Robert Burns, Amit Khandhar,Steven Reed,George Pavlakis

The Journal of Immunologyno. 1_Supplement (2024): 1013_5460-1013_5460

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Efficient Ex Vivo Expansion of Conserved Element Vaccine-Specific CD8+T-cells from SHIV-infected, ART-suppressed Nonhuman Primates

Sandra Dross,Rasika Venkataraman,Shabnum Patel,Meei-Li Huang,Catherine M. Bollard,Margherita Rosati,George N. Pavlakis,Barbara K. Felber,Katharine J. Bar,George M. Shaw,Keith R. Jerome,James I. Mullins,Hans-Peter Kiem,Deborah Heydenburg Fuller,Christopher W. Peterson

FRONTIERS IN IMMUNOLOGY (2023)

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First-in-human Phase I/Ib Study of NIZ985, a Recombinant Heterodimer of IL-15 and IL-15Rα, As a Single Agent and in Combination with Spartalizumab in Patients with Advanced and Metastatic Solid Tumors

Rom Leidner,Kevin Conlon,Douglas G. Mcneel,Andrea Wang-Gillam,Sumati Gupta,Robert Wesolowski,Monica Chaudhari,Nadia Hassounah,Jong Bong Lee,Lang Ho Lee, Jessica A. O'Keeffe,Nancy Lewis,George N. Pavlakis,John A. Thompson

Journal for ImmunoTherapy of Cancer（2023）

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Heterodimeric IL-15 (Hetil-15) Reduces Circulating Tumor Cells and Metastasis Formation Improving Chemotherapy and Surgery in 4T1 Mouse Model of TNBC

Vasiliki Stravokefalou,Dimitris Stellas,Sevasti Karaliota,Bethany A. Nagy,Antonio Valentin,Cristina Bergamaschi,Konstantinos Dimas,George N. Pavlakis

Frontiers in Immunology（2023）

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Rapid Transient and Longer-Lasting Innate Cytokine Changes Associated with Adaptive Immunity after Repeated SARS-CoV-2 BNT162b2 Mrna Vaccinations

Margherita Rosati,Evangelos Terpos,Philip Homan,Cristina Bergamaschi,Sevasti Karaliota,Ioannis Ntanasis-Stathopoulos,Santhi Devasundaram,Jenifer Bear,Robert Burns,Tina Bagratuni,Ioannis P. Trougakos,Meletios A. Dimopoulos,George N. Pavlakis,Barbara K. Felber

Frontiers in immunology (2023)

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Abstract 5082: Heterodimeric IL-15 (Hetil-15) Immunotherapy Synergizes with Fatty Acid Metabolism Modulator (FAMM) to Eradicate TNBC EO771 Murine Tumors

Sevasti Karaliota,Dimitris Stellas,Vasiliki Stravokefalou,Breana Myers, Barbara K. Felber,George N. Pavlakis

CANCER RESEARCHno. 7 (2023)

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Scientist Emeritus

Papers共 598 篇Author StatisticsCo-AuthorSimilar Experts