Prof. Leone is an interventional cardiologist particularly experienced in the field of invasive coronary physiology and is the creator of a simplified functional evaluation method that exploits the vasodilatory properties of the contrast medium called cFFR. With his research group he has carried out several clinical studies, also in collaboration with important Italian and foreign institutions, which have documented the safety and effectiveness of a "physiological" approach to coronary angioplasty. These studies led to the definition of a decision-making algorithm in coronary intervention procedures, now known internationally as "#FullPhysiology". The UOC of Diagnostic and Interventional Cardiology - UTIC is also very active in the field of Heart Failure, regularly participating in clinical trials in collaboration with the National Scientific Societies of Cardiology.