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Our laboratory is interested in the pathogenesis of bacterial infections and the development of vaccines for their prevention. The primary focus is on a system we discovered that allows certain Gram-negative bacteria to obtain iron for growth in vivo by directly obtaining iron from the host's iron binding proteins, transferrin and lactoferrin. This system involves receptors at the bacterial surface that bind transferrin or lactoferrin as a first step in the iron acquisition process. The two main goals of our research are to determine the detailed mechanisms involved in the iron uptake pathway and to develop effective vaccines and therapeutic agents against pathway components.
The surface receptors are essential for survival of the bacteria in vivo, indicating that they are ideal vaccine targets. Receptor proteins from different bacteria that cause meningitis, lung infections and ear infections in humans and pneumonia in cattle and pigs have been tested for efficacy and licensed to companies interested in developing human and veterinary vaccines. However, vaccine development is currently hampered by antigenic variation of the receptor proteins. Our goal is to develop effective, broad-spectrum, long-lasting vaccines based on the conserved regions of the receptor proteins that are required for function.
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Papers共 133 篇Author StatisticsCo-AuthorSimilar Experts
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Jamie E Fegan,Epshita A Islam,David M Curran, Dixon Ng, Natalie Au, Elissa G Currie, Joseph Zeppa,Jessica Lam,Anthony B Schryvers,Trevor F Moraes,Scott D Gray-Owen
bioRxiv the preprint server for biology (2024)
Jamie E Fegan, Regula C Waeckerlin,Liyuwork Tesfaw,Epshita A Islam,Getaw Deresse, Dawit Dufera, Eyob Assefa, Wubet Woldemedhin,Abinet Legesse,Mirtneh Akalu,Berecha Bayissa, Quynh Huong Nguyen,Dixon Ng,Sang Kyun Ahn,Anthony B Schryvers,Takele A Tefera,Trevor F Moraes,Scott D Gray-Owen
Frontiers in immunology (2024): 1392681-1392681
PNAS NEXUSno. 4 (2024): pgae139-pgae139
Isaac S Lee,Jamie E Fegan, Elissa G Currie, Anna Bojagora,Nelly Y Leung, Derrick Rancourt, Muhamed-Kheir Taha,Anthony B Schryvers,Scott D Gray-Owen
bioRxiv the preprint server for biology (2024)
Epshita M. Islam,Jamie C. Fegan,Takele Tefera,David Curran, Regula Waeckerlin,Dixon Ng,Sang Kyun Ahn, Chun Heng Royce Lai, Quynh Huong Nguyen,Megha W. Shah,Liyuwork Tesfaw,Kassaye Adamu, Wubet Medhin,Abinet Legesse,Getaw Deresse,Belayneh Getachew,Neil B. Rawlyk,Brock D. Evans,Andrew F. Potter,Anthony Schryvers,Scott Gray-Owen,Trevor Moraes
Somshukla Chaudhuri,Iraj Rasooli, Ramin Hatefi Oskouei,Mahdi Pishgahi,Abolfazl Jahangir,Vahid Farshchi Andisi,Anthony B. Schryvers
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#Papers: 133
#Citation: 3161
H-Index: 31
G-Index: 47
Sociability: 6
Diversity: 0
Activity: 1
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