She has worked in research in the epidemiology and prevention of HIV and sexually transmitted infections and other infectious diseases including influenza, antimicrobial resistance and COVID-19 for over 35 years. She was principal investigator on the 1990 first National Survey of Sexual Attitudes and Lifestyles (Natsal 1990), Natsal 2000 and on MRC/Wellcome Trust funded Natsal 2010. Her research portfolio includes international HIV cohort studies, behavioural intervention studies and community study of the epidemiological and immunological determinants of seasonal influenza transmission (MRC Fluwatch). She was a co-investigator on the UCL I-Sense project developing novel diagnostics and pathways for infectious disease detection. She is a co-investigator on Virus watch a major population study of Covid -9 transmission. Her studies have included include collaborations with colleagues in Europe, Africa and China.