Research
Autophagy is a major degradation pathway in the cell. While the ubiquitin/proteasome system degrades proteins, autophagy degrades bulk cytoplasmic material. Autophagosomes have been shown to engulf whole organelles, such as mitochondria, lipid droplets and ER and as a consequence autophagy impacts on metabolism, apoptosis, differentiation, cell cycle and cell fate decisions in the cell.

Over the last decade we have studied the role of autophagy in the development and function of hematopoietic and immune cells using in vivo models and in vitro techniques applied to human samples.