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个人简介
Dr. Anil Shanker leads the Laboratory of Lymphocyte Function in the Department of Biochemistry and Cancer Biology at Meharry Medical College School of Medicine. He is also a member of the Host-Tumor Interactions Research Program of Vanderbilt-Ingram Comprehensive Cancer Center (VICC) at Vanderbilt University.
The Shanker laboratory studies information processing and molecular circuitry underlying lymphocyte crosstalk. Using the TCR-transgenic mice specific to cancer-germline self-antigen P1A, akin to human MAGE antigens (J Immunol 172:5069), our pioneering studies discovered a paradigm of CD8 T cell help for innate NK effector function in solid tumor microenvironments. Such a potentiated CD8 T–NK crosstalk enhances immunosurveillance against tumor development and prevents tumor escape (J Immunol 179:6377). Our ongoing work has identified mitochondrial Ca2+ transport-mediated intermembranous interaction critical during CD8 T–NK cooperativity to elicit NK cell effector/regulatory and T cell memory functions. We also found that CD8 T cells preferentially use death ligands to clear metastasis of tumor cells expressing low-avidity antigens (Cancer Res 69:6615). These findings provide for novel immunotherapy approaches that we are exploring to prevent tumor development, escape and metastasis. In breast, kidney and inducible EGFR-mutant lung cancer mouse models, and patient samples in a multi-institutional collaboration, we are testing adoptive transfer protocols of CD8 T and NK cells in combination with engineered Notch ligand constructs (Cancer Res 71:6122, 75:4728; JITC 7:95), bortezomib, a proteasome inhibitor (J Immunol 180:163; JNCI 100:649; Cancer Res 75:5260), and neurotransmitter agonists. Our efforts are also invested in building computational models that guide cell fate and lymphocyte functional crosstalk (Open Biol 6:160192; Front Immunol 10:1906). The laboratory provides a vibrant research environment for mentoring its undergrad, doctoral, postdoctoral and medical trainees from diverse backgrounds.
The Shanker laboratory studies information processing and molecular circuitry underlying lymphocyte crosstalk. Using the TCR-transgenic mice specific to cancer-germline self-antigen P1A, akin to human MAGE antigens (J Immunol 172:5069), our pioneering studies discovered a paradigm of CD8 T cell help for innate NK effector function in solid tumor microenvironments. Such a potentiated CD8 T–NK crosstalk enhances immunosurveillance against tumor development and prevents tumor escape (J Immunol 179:6377). Our ongoing work has identified mitochondrial Ca2+ transport-mediated intermembranous interaction critical during CD8 T–NK cooperativity to elicit NK cell effector/regulatory and T cell memory functions. We also found that CD8 T cells preferentially use death ligands to clear metastasis of tumor cells expressing low-avidity antigens (Cancer Res 69:6615). These findings provide for novel immunotherapy approaches that we are exploring to prevent tumor development, escape and metastasis. In breast, kidney and inducible EGFR-mutant lung cancer mouse models, and patient samples in a multi-institutional collaboration, we are testing adoptive transfer protocols of CD8 T and NK cells in combination with engineered Notch ligand constructs (Cancer Res 71:6122, 75:4728; JITC 7:95), bortezomib, a proteasome inhibitor (J Immunol 180:163; JNCI 100:649; Cancer Res 75:5260), and neurotransmitter agonists. Our efforts are also invested in building computational models that guide cell fate and lymphocyte functional crosstalk (Open Biol 6:160192; Front Immunol 10:1906). The laboratory provides a vibrant research environment for mentoring its undergrad, doctoral, postdoctoral and medical trainees from diverse backgrounds.
研究兴趣
论文共 162 篇作者统计合作学者相似作者
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Tanu Rana,Olga Y. Korolkova, Girish Rachakonda,Amanda D. Williams, Alexander T. Hawkins,Samuel D. James,Amos M. Sakwe,Hui Nian,Li Wang,Chang Yu, Jeffrey S. Goodwin,Michael G. Izban, Regina S. Offodile,Mary K. Washington,Billy R. Ballard,Duane T. Smoot,Xuan-Zheng Shi, Digna S. Forbes,Anil Shanker, Amosy E. M'Koma
PLOS ONEno. 5 (2024)
Cancersno. 3 (2024): 670-670
PloS oneno. 5 (2024): e0304732-e0304732
Thanigaivelan Kanagasabai, Mariam Hawaz, Kayla Ellis, Orlyne Fah, Helana Mikhaeil, Philip Nguyen, Nathalie Tombo,Anil Shanker,Chethan Sampath,Zaid H Khoury, James Cade, Alexys Ferguson,Pandu Gangula
Dental research and oral healthno. 02 (2024)
Tonie Farris, Salvador Gonzalez-Ochoa, Muna Mohammed, Harshana Rajakaruna,Jane Tonello,Thanigaivelan Kanagasabai,Olga Korolkova,Akiko Shimamoto,Alla Ivanova,Anil Shanker
International Journal of Molecular Sciencesno. 13 (2024): 7406
Cancer Researchno. 6_Supplement (2024): 3158-3158
Rabi Thangaiyan,Amos M Sakwe, Alexander T Hawkins,Mary K Washington,Billy R Ballard,Michael G Izban, Sanika S Chirwa,James E K Hildreth,Anil Shanker, David L Blum, Amosy E M'Koma
Research square (2024)
Handbook of Cancer and Immunologypp.1-20, (2023)
Anil Shanker, Alan D. Brooks, Kristen M. Jacobsen, John W. Wine, Robert H. Wiltrout,Hideo Yagita, Thomas J. Sayers
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作者统计
#Papers: 162
#Citation: 2087
H-Index: 27
G-Index: 44
Sociability: 8
Diversity: 0
Activity: 1
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