基本信息
views: 2
Career Trajectory
Bio
He did his graduate work at the University of Manchester in Stephen Taylor’s lab. While there, he studied the regulation of a protease that is responsible for dissolving the “glue” that holds the replicated sister chromatids together during mitosis.
Cell division is a fundamental process forming the basis for life itself. Each time a cell divides, it makes a complete copy of its entire genome and segregates this genome such that both daughter cells receive all the genetic information required for further growth and development. Errors in the distribution of chromosomes during mitosis lead to the production of cells with an abnormal chromosome content, which in early development lead to lethal growth defects and may later contribute to the development of cancer.
The Holland lab is investigating in the molecular mechanisms that control accurate chromosome distribution and the role that mitotic errors play in human health and disease. Our work utilizes a combination of chemical biology, biochemistry, cell biology and genetically engineered mice to study pathways involved in mitosis and their effect on cell and organism physiology. A major focus of the group is to develop cell and animal-based models to study the role of cell division defects in genome instability and tumorigenesis.
Cell division is a fundamental process forming the basis for life itself. Each time a cell divides, it makes a complete copy of its entire genome and segregates this genome such that both daughter cells receive all the genetic information required for further growth and development. Errors in the distribution of chromosomes during mitosis lead to the production of cells with an abnormal chromosome content, which in early development lead to lethal growth defects and may later contribute to the development of cancer.
The Holland lab is investigating in the molecular mechanisms that control accurate chromosome distribution and the role that mitotic errors play in human health and disease. Our work utilizes a combination of chemical biology, biochemistry, cell biology and genetically engineered mice to study pathways involved in mitosis and their effect on cell and organism physiology. A major focus of the group is to develop cell and animal-based models to study the role of cell division defects in genome instability and tumorigenesis.
Research Interests
Papers共 117 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Marina A. Schapfl,Gina M. LoMastro, Vincent Z. Braun, Maretoshi Hirai,Michelle S. Levine, Eva Kiermaier, Verena Labi,Andrew J. Holland,Andreas Villunger
NATURE COMMUNICATIONSno. 1 (2024)
Ana Curinha, Zhaoyu Huang, Taylor Anglen,Margaret A. Strong,Colin R. Gliech,Cayla E. Jewett,Anoek Friskes,Andrew J. Holland
bioRxiv the preprint server for biology (2024)
bioRxiv the preprint server for biology (2024)
bioRxiv the preprint server for biology (2024)
biorxiv(2024)
Colin R Gliech,Zhong Y Yeow,Daniel Tapias-Gomez,Yuchen Yang, Zhaoyu Huang,Andréa E Tijhuis,Diana CJ Spierings,Floris Foijer,Grace Chung,Nuria Tamayo, Zahra Bahrami-Nejad, Patrick Collins,Thong T Nguyen, Andres Plata Stapper,Paul E Hughes,Marc Payton,Andrew J Holland
The EMBO Journalno. 5 (2024): 666-694
biorxiv(2024)
bioRxiv the preprint server for biology (2024)
Marnie W. Skinner, Carter J. Simington,Pablo Lopez-Jimenez,Kerstin A. Baran, Jingwen Xu, Yaron Dayani,Marina Pryzhkova,Jesus Page,Rocio Gomez,Andrew J. Holland,Philip W. Jordan
EMBO REPORTSno. 8 (2024): 3373-3405
JOURNAL OF CELL BIOLOGYno. 1 (2023)
Load More
Author Statistics
#Papers: 118
#Citation: 7537
H-Index: 42
G-Index: 86
Sociability: 6
Diversity: 0
Activity: 1
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn