My group's work and that of others in ophthalmology focuses on how the retina responds to injury, inflammation and degeneration. This covers areas which include: The control of immune responses in the retina which includes for example the interaction with microglia and inhibitory signals mediated by neuronal CD200 expression Autoimmune responses within the eye and brain, by studying both T cell and macrophage responses within the tissue during experimental retinal and CNS autoimmunity Microglial and macrophage behaviour during retinal degeneration by studying experimental models of photoreceptor degeneration Retinal remodelling by studying the interaction of microglia, Muller cells and retinal progenitor cells Role of macrophages in retinal and choroidal angiogenesis Development of immunomodulatory agents for the treatment of uveitis, investigated in the experimental model of uveitis