基本信息
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职业迁徙
个人简介
In the Walhout lab we aim to understand how biological networks are organized, how their organization enables function, and how these networks evolve. Our main focus is on the gene regulatory networks that control proper gene expression, and on metabolic networks that provide building blocks and energy to support organism development, growth, wound healing, homeostasis, and response to nutritional, environmental and therapeutic inputs. We are particularly interested in the communication between metabolic and gene regulatory networks to ask important questions that navigate both broad systems-level as well as deep mechanistic biological processes. We mainly use the roundworm Caenorhabditis elegans as a model system. Worms are highly adaptable, easy to manipulate, and have many analogs in human genetics. Furthermore, there are many genetic tools and worm-specific techniques that are not available for studying “higher” eukaryotes. Overall, our research involves three broad areas in systems biology:
NETWORK STRUCTURE, FUNCTION AND EVOLUTION
TISSUE-RELEVANT NETWORKS
HOST-MICROBIOTA INTERACTIONS IN NUTRITION AND DRUG RESPONSE
NETWORK STRUCTURE, FUNCTION AND EVOLUTION
TISSUE-RELEVANT NETWORKS
HOST-MICROBIOTA INTERACTIONS IN NUTRITION AND DRUG RESPONSE
研究兴趣
论文共 150 篇作者统计合作学者相似作者
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期刊级别
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合作机构
PLOS BIOLOGYno. 4 (2023): e3002057-e3002057
Molecular Systems Biologyno. 5 (2023)
bioRxiv (Cold Spring Harbor Laboratory)no. 7 (2023)
NATUREno. 7987 (2023): 625-+
Cell reportsno. 10 (2023): 113189-113189
Woo Kyu Kang, Antonia Araya,Bennett W. Fox,Andrea Thackeray,Frank C. Schroeder,Albertha J.M. Walhout,Mark J. Alkema
biorxiv(2022)
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