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Dr. Garg and his collaborators at the National Institutes of Diabetes, Digestive and Kidney Diseases, NIH reported beneficial effects of leptin replacement therapy on glycemic control, lipoprotein levels and hepatic steatosis in patients with severe lipodystrophy and leptin deficiency. This study was published in the New England Journal of Medicine. Leptin is a hormone produced by the adipose tissue (body fat) and regulates appetite and energy expenditure. This landmark study supports the role of leptin deficiency as a major contributor to the insulin resistance and other metabolic abnormalities seen in severe lipodystrophy. Furthermore, leptin therapy may become the choice of therapy for treating these severely insulin resistant patients with lipodystrophies. Dr. Garg is now initiating studies to investigate whether leptin therapy will improve metabolic complication in hypoleptinemic patients with partial lipodystrophies. Recently, he identified two patterns of lipodystrophy in patients with mandibuloacral dysplasia which has led him to identify another gene, ZMPSTE24 besides LMNA, for this disorder.
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Papers共 299 篇Author StatisticsCo-AuthorSimilar Experts
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Nature Reviews Endocrinologyno. 3 (2024): 128-129
Gulcin Akinci,Saif Alyaarubi,Nivedita Patni,Nadia Alhashmi,Azza Al-Shidhani,Flavia Prodam,Nancy Gagne,Funmbi Babalola,Aisha Al Senani,Kavitha Muniraj,Solaf M. Elsayed,Marianna Beghini,Basak Ozgen Saydam,Moosa Allawati,Madhumati S. Vaishnav, Ender Can,Ilgin Y. Simsir,Ekaterina Sorkina,Fatma Dursun,Clemens Kamrath,Umit Cavdar,Partha P. Chakraborty,Ozlem Akgun Dogan, Aliya Al Hosin, Ashwaq Al Maimani, Nil Comunoglu, Ahmed Hamed, Tea Huseinbegovic,Thomas Scherer,Jacqueline Curtis,Rebecca J. Brown,Vinaya Simha,Martin Wabitsch,Beyhan Tuysuz,Haluk Topaloglu,Elif A. Oral,Baris Akinci,Abhimanyu Garg
American journal of medical genetics Part A (2024)
ISCIENCEno. 4 (2024): 109517-109517
Go Eun Kwon,Hyun-Hwa Son,Ju-Yeon Moon, Ayoung Lee, Mo Kyung Jung, Seonkyeong Rhie,Mi Jung Park,Abhimanyu Garg,Eun-Gyong Yoo,Man Ho Choi
Clinica Chimica Acta (2024): 119886-119886
JCEM case reportsno. 5 (2024)
ISCIENCEno. 1 (2024): 108653-108653
JCEM case reportsno. 10 (2024): luae166-luae166
Ben Olenchock,Simona Podgrabinska, Chia-Chung Hou,Bret J. Musser,Jeanne Mendell, Amy Harman, Robert J. Sanchez, Kathryn Miller,Prodromos Parasoglou,Stefanie J. Hectors,Satyajit K. Karnik,Odelya E. Pagovich, Ranabir SinhaRoy,Charles Harris,Barış Akinci,Ilgın Yıldırım Şimşir,Samim Özen,Ekaterina Sorkina,Abhimanyu Garg, R. González,David M. Weinreich,Gary Herman,Elif A. Oral,Rebecca J. Brown
Journal of the Endocrine Societyno. Supplement_1 (2023)
Molecular genetics & genomic medicineno. 1 (2023)
iScienceno. 10 (2023): 107806-107806
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Author Statistics
#Papers: 297
#Citation: 21910
H-Index: 73
G-Index: 145
Sociability: 7
Diversity: 0
Activity: 1
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