Yesim Orhun's research program focuses on exploring questions related to the relationship between market structure, product provision and price discrimination; and, the relationship between beliefs and utility. She primarily uses empirical methods in studying product provision and price discrimination, and experimental methods in studying beliefs. Her research projects oftentimes offer a novel identification approach based on a theoretical and inter-disciplinary perspective that combines her background in Industrial Organization and Behavioral Economics.

She brings new insights from research to the classroom. When searching for a better strategy in complex business situation, she encourages students to employ critical thinking about possible strategies by identifying the relevant questions for the problem at hand, collecting and analyzing data to answer them while considering competitors' and consumers' reactions.