My research interests lie in host-pathogen interactions and the molecular basis of virulence. My research is broad-ranging and multidisciplinary, from understanding the roles of individual bacterial proteins in virulence, studying the within-host population dynamics of bacterial pathogens and understanding the host response to infection. My research focuses on bacterial pathogens of veterinary and clinical significance, including; enteropathogenic Escherichia coli (EPEC), Campylobacter jejuni and Salmonella enterica. I aim to use integrated approaches where advanced molecular, genomic, proteomic and microscopy techniques, in combination with mathematical and statistical models, enable me to tease out heterogeneous events in infection. My recent work has concentrated on a systems-level in vivo analysis of Salmonella-host interactions, to provide the mechanistic detail to describe infective disease within the host.