My research focuses on immunotherapy in cancer with a special focus on skin cancers such as melanoma. I have designed and conducted numerous Phase I and II clinical trials. A collaboration with Dr Richard Heller has resulted in intratumoral IL12 as a treatment for melanoma. At UCSF, I co-direct the melanoma program and am the PI of several early phase and melanoma specific clinical trials as well as collaborating with my colleagues Michael Rosenblum, Max Krummel, Matt Spitzer and Jeff Bluestone at UCSF as well as other national experts in melanoma patients progressing on immunotherapy. One of the areas I am interested in is immunotherapy with PD-1 antibodies and in understanding resistance to PD-1 especially site specific immunity.