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John L. Bixby
Professor
Department of Neurological Surgery
Miller School of Medicine, University of Miami;The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine;Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami
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Bio
RESEARCH INTERESTS
Phenotypic Sceening, Axon Regeneration, and Drug Discovery
Transcription factors in Axon Growth
Our focus is on understanding and overcoming barriers to axon regeneration after injury to the central nervous system (CNS). We use various strategies to identify and manipulate molecular targets to promote this regeneration. When Dr. Vance Lemmon and I established our joint lab in 2003, we adopted two core technologies: phenotypic screening and transcriptomics. This combination was powerful and resulted in the identification of KLF family members as important regulators of CNS axon regeneration (Moore et al, 2010, Science, 326: 298; Blackmore et al, 2012, PNAS (USA) 109: 7517). We also did extensive work on other transcription factors such as STAT3 and Jun family members (Smith et al, 2011, Mol Cell Neurosci 46: 32; Lerch et al, 2014, Mol Cell Neurosci, 59: 97; Luo et al, 2016, Cell Rep, 15: 398; Mehta et al, 2016, Exp Neurol, 280: 115; Danzi et al, 2018, Mol Cell Neurosci 92: 114).
Research Interests
Papers共 176 篇Author StatisticsCo-AuthorSimilar Experts
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JOURNAL OF NEUROTRAUMAno. 15-16 (2023): A29-A30
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Kar Men Mah,Wei Wu,Hassan Al-Ali,Yan Sun,Qi Han,Ying Ding, Melissa Muñoz,Xiao-Ming Xu,Vance P Lemmon,John L Bixby
Experimental neurology (2023): 114669-114669
JOURNAL OF RESEARCH ADMINISTRATIONno. 1 (2022): 144-161
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Informing Sci. Int. J. an Emerg. Transdiscipl. (2021): 083-110
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#Papers: 178
#Citation: 10838
H-Index: 54
G-Index: 54
Sociability: 6
Diversity: 4
Activity: 65
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