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个人简介
Starting in 1997, my group has been studying genes and proteins that affect drug resistance in tumors, or influence the pharmacological and toxicological behavior of (anticancer) drugs and toxins, including carcinogens. Of special interest are multispecific drug efflux and uptake transporters, as well as drug-metabolizing enzymes. Insight into these systems may: i) improve pharmacotherapy approaches for cancer and other diseases; ii) increase insights into factors determining susceptibility to toxins and carcinogens, and; iii) allow elucidation of physiological functions. To understand the roles of these proteins we often generate and analyze knockout or transgenic mice lacking or overexpressing the relevant genes.
研究兴趣
论文共 362 篇作者统计合作学者相似作者
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International journal of pharmaceutics (2024): 123708-123708
Cancer chemotherapy and pharmacologyno. 1 (2024): 79-87
Clinical and translational scienceno. 1 (2024): e13668-e13668
Jamie Rijmers,Irene A. Retmana, Viët Bui, Davinia Arguedas,Maria C. Lebre,Rolf W. Sparidans,Jos H. Beijnen,Alfred H. Schinkel
Biomedicine & Pharmacotherapy (2024): 116720-116720
Toxicology and Applied Pharmacologypp.117040, (2024)
Toxicology and applied pharmacology (2024): 116911-116911
MOLECULAR PHARMACEUTICSno. 5 (2023): 2477-2489
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作者统计
#Papers: 380
#Citation: 39987
H-Index: 98
G-Index: 196
Sociability: 7
Diversity: 4
Activity: 56
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