Joseph Ware - Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development

基本信息

Career Trajectory

Bio

Joseph Ware works at the interface of clinical and quantitative pharmacology to impact drug development. Currently, he is a Senior Director Clinical Pharmacology at Seagen. Prior to Seagen he worked at Denali, AstraZeneca, Genentech, Pfizer, and Pharmacy.

Research Interests

Papers共 110 篇Author StatisticsCo-AuthorSimilar Experts

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Using Clinical Utility Index (CUI) to Determine the Optimal Biological Dose of a Nonfucosylated Anti-Tigit Antibody: A Proposed Alternative to Maximum Tolerated Dose (MTD)

Gabriela Patilea-Vrana,John Harrold,Joseph A. Ware, Shaparak Lonning, Hun Lee, Lisa Brooks,Haley Neff-LaFord,William D. Hanley,Andres Forero-Torres

Cancer researchno. 7_Supplement (2023): 5668-5668

Cited0Views0Bibtex

Abstract 5060: Tucatinib Does Not Alter Oxaliplatin PK or Associated Renal Function: an OCT2 and MATE Transport Inhibition Study

Ariel R. Topletz‐Erickson,Anthony Lee,Vineet Kumar, Michelle Ubowski,JoAl Mayor,Layth I. Abdulrasool,Clark M. Henderson,Joseph A. Ware,Christopher J. Endres

Cancer researchno. 7_Supplement (2023): 5060-5060

Cited0Views0Bibtex

Supplementary Figure Legend from Bridging the Gap Between Preclinical and Clinical Studies Using Pharmacokinetic–Pharmacodynamic Modeling: an Analysis of GDC-0973, a MEK Inhibitor

Harvey Wong,Laurent Vernillet,Amy Peterson,Joseph A. Ware,Lillian Lee,Jean-Francois Martini,Peiwen Yu,Congfen Li,Geoffrey Del Rosario,Edna F. Choo,Klaus P. Hoeflich,Yongchang Shi,Blake T. Aftab,Ron Aoyama,Sanh Tan Lam,Marcia Belvin,John Prescott

pubmed（2023）

Cited73Views0WOSBibtex

Absorption, Metabolism, and Excretion of Taselisib (GDC-0032), a Potent β-Sparing PI3K Inhibitor in Rats, Dogs, and Humans

Shuguang Ma,Sungjoon Cho,Srikumar Sahasranaman,Weiping Zhao,Jodie Pang,Xiao Ding,Brian Dean, Bin Wang,Jerry Y Hsu,Joseph Ware,Laurent Salphati

Drug metabolism and disposition: the biological fate of chemicals（2023）

Cited2Views0WOSBibtex

Supplemental Data from Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors

Saoirse O. Dolly,Andrew J. Wagner,Johanna C. Bendell, Hedy L. Kindler,Lee M. Krug,Tanguy Y. Seiwert,Marjorie G. Zauderer,Martijn P. Lolkema,Doris Apt,Ru-Fang Yeh,Jill O. Fredrickson,Jill M. Spoerke, Hartmut Koeppen,Joseph A. Ware,Jennifer O. Lauchle,Howard A. Burris,Johann S. de Bono

openalex（2023）

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Quantitative Systems Pharmacology Model‐based Investigation of Adverse Gastrointestinal Events Associated with Prolonged Treatment with PI3‐kinase Inhibitors

Kapil Gadkar,Christina Friedrich,Vincent Hurez, Maria-Luisa Ruiz,Leslie Dickmann, Mohit Kumar Jolly,Leah Schutt, Jin,Joseph A. Ware,Saroja Ramanujan

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGYno. 5 (2022): 616-627

Cited5Views0WOSBibtex

Bioequivalence and Relative Bioavailability Studies to Assess a New Acalabrutinib Formulation That Enables Coadministration with Proton‐Pump Inhibitors

Shringi Sharma,Xavier Pepin,Harini Burri,Lianqing Zheng,Nataliya Kuptsova-Clarkson,Anouk de Jong, Ting Yu,Holly L. MacArthur,Michal Majewski,John C. Byrd,Richard R. Furman,Joseph A. Ware,James Mann,David Ramies,Veerendra Munugalavadla,Louise Sheridan,Helen Tomkinson

Clinical pharmacology in drug developmentno. 11 (2022): 1294-1307

Cited3Views0WOSBibtex

Evaluation of the Pharmacokinetics and Safety of a Single Dose of Acalabrutinib in Subjects With Hepatic Impairment

Yan Xu,Raquel Izumi, Helen Nguyen, Anna Kwan, Howard Kuo, Jeannine Madere,J. Greg Slatter,Terry Podoll,Karthick Vishwanathan,Thomas Marbury,William Smith,Richard A. Preston,Shringi Sharma,Joseph A. Ware

JOURNAL OF CLINICAL PHARMACOLOGY（2022）

Cited1Views0WOSBibtex

Bioavailability of Acalabrutinib Suspension Delivered Via Nasogastric Tube in the Presence or Absence of a Proton Pump Inhibitor in Healthy Subjects

Shringi Sharma,Xavier Pepin,Jean Cheung,Lianqing Zheng, Hua Wei,Danielle Townsley,David Han,Michal Majewski,Joseph A. Ware,James Mann,Veerendra Munugalavadla,Louise Sheridan,Priti Patel,Ashok Gupta,Helen Tomkinson

British Journal of Clinical Pharmacology（2022）

Cited1Views0WOSBibtex

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